Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study
Abstract Background Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, with antibody-mediated immune responses to infectious diseases agents potentially playing a decisive role in its pathophysiological process. However, the causal relationship between antibodies and AD remains uncl...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Hereditas |
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| Online Access: | https://doi.org/10.1186/s41065-024-00358-4 |
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| author | Jiayuan Zhang Mingming Wang Dong Wang Linwen Deng Yao Peng |
| author_facet | Jiayuan Zhang Mingming Wang Dong Wang Linwen Deng Yao Peng |
| author_sort | Jiayuan Zhang |
| collection | DOAJ |
| description | Abstract Background Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, with antibody-mediated immune responses to infectious diseases agents potentially playing a decisive role in its pathophysiological process. However, the causal relationship between antibodies and AD remains unclear. Methods A two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal link between antibody-mediated immune responses to infectious diseases agents and the risk of AD. Genetic variations associated with these antibodies obtained from UK Biobank, and data on AD were obtained from the Finnish databases, utilizing its extensive repository of genome-wide association studies (GWAS) for a comprehensive analysis. The MR analysis employed the inverse variance-weighted, MR-Egger, and weighted median methods. Sensitivity analysis was also performed using MR-Egger regression, MR-pleiotropy residual sum, and outlier tests. Results Two causal associations were identified between antibody-mediated immune responses to infectious diseases agents and AD. Varicella zoster virus glycoproteins E and I antibody suggest a protective association with AD. Conversely, higher levels of Epstein-Barr virus EBNA-1 antibody appear to be associated with an increased risk of AD. Conclusion Our MR analysis has revealed a causal relationship between antibody-mediated immune responses to specific infectious disease agents and AD. These findings provide valuable insights into the pathophysiological mechanisms underlying AD. |
| format | Article |
| id | doaj-art-1800dfe3ba7e4e0891a15ff348c4b747 |
| institution | Kabale University |
| issn | 1601-5223 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditas |
| spelling | doaj-art-1800dfe3ba7e4e0891a15ff348c4b7472025-01-05T12:32:20ZengBMCHereditas1601-52232025-01-0116211810.1186/s41065-024-00358-4Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization studyJiayuan Zhang0Mingming Wang1Dong Wang2Linwen Deng3Yao Peng4Sichuan Police CollegeSichuan Police CollegeSichuan Police CollegeDepartment of Gynecology, Hospital of Chengdu University of Traditional Chinese MedicineThe Affiliated Traditional Chinese Medicine Hospital, Southwest Medical UniversityAbstract Background Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, with antibody-mediated immune responses to infectious diseases agents potentially playing a decisive role in its pathophysiological process. However, the causal relationship between antibodies and AD remains unclear. Methods A two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal link between antibody-mediated immune responses to infectious diseases agents and the risk of AD. Genetic variations associated with these antibodies obtained from UK Biobank, and data on AD were obtained from the Finnish databases, utilizing its extensive repository of genome-wide association studies (GWAS) for a comprehensive analysis. The MR analysis employed the inverse variance-weighted, MR-Egger, and weighted median methods. Sensitivity analysis was also performed using MR-Egger regression, MR-pleiotropy residual sum, and outlier tests. Results Two causal associations were identified between antibody-mediated immune responses to infectious diseases agents and AD. Varicella zoster virus glycoproteins E and I antibody suggest a protective association with AD. Conversely, higher levels of Epstein-Barr virus EBNA-1 antibody appear to be associated with an increased risk of AD. Conclusion Our MR analysis has revealed a causal relationship between antibody-mediated immune responses to specific infectious disease agents and AD. These findings provide valuable insights into the pathophysiological mechanisms underlying AD.https://doi.org/10.1186/s41065-024-00358-4AntibodiesAlzheimer’s diseaseCausalityGWASMendelian randomization |
| spellingShingle | Jiayuan Zhang Mingming Wang Dong Wang Linwen Deng Yao Peng Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study Hereditas Antibodies Alzheimer’s disease Causality GWAS Mendelian randomization |
| title | Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study |
| title_full | Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study |
| title_fullStr | Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study |
| title_full_unstemmed | Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study |
| title_short | Alzheimer’s disease and antibody-mediated immune responses to infectious diseases agents: a mendelian randomization study |
| title_sort | alzheimer s disease and antibody mediated immune responses to infectious diseases agents a mendelian randomization study |
| topic | Antibodies Alzheimer’s disease Causality GWAS Mendelian randomization |
| url | https://doi.org/10.1186/s41065-024-00358-4 |
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