TNF-α modulates cell proliferation via SOX4/TGF-β/Smad signaling in benign prostatic hyperplasia

TNF-α modulates cell proliferation via SOX4/TGF-β/Smad signaling in benign prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is an age-related condition in men with a poorly defined etiology. Chronic inflammation is increasingly recognized as a key contributor to BPH progression; however, the underlying mechanisms remain incompletely understood. This study aimed to elucidate the...

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Main Authors: Jinze Li, Bo Chen, Yin Huang, Xinyang Liao, Jia You, Zeyu Chen, Shu Ning, Asmaa Reda, Junwei Zhao, Biao Ran, Jingxing Bai, Mengli Zhu, Yan Wang, Hongying Chen, Qiang Wei, Dehong Cao, Liangren Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07783-x
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