1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction
We presented a case of a 72-year-old male with severe hypercalcaemia of 3.84 mmol/L following the second cycle of immunotherapy with ipilimumab and nivolumab in the setting of metastatic melanoma with known bone metastases. Further investigations demonstrated hilar lymphadenopathy, which was not pre...
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Bioscientifica
2025-02-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
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| author | R K Dharmaputra N Sheriff S Ravichandran |
| author_facet | R K Dharmaputra N Sheriff S Ravichandran |
| author_sort | R K Dharmaputra |
| collection | DOAJ |
| description | We presented a case of a 72-year-old male with severe hypercalcaemia of 3.84 mmol/L following the second cycle of immunotherapy with ipilimumab and nivolumab in the setting of metastatic melanoma with known bone metastases. Further investigations demonstrated hilar lymphadenopathy, which was not present in previous imaging, and subsequent hypercalcaemia work-up demonstrated a significantly elevated serum calcitriol level as high as 429 pmol/L. A diagnosis of drug-induced sarcoid-like reactions or DISRs was made on the basis of hypercalcaemia and hilar lymphadenopathy following immunotherapy. Hypercalcaemia was effectively treated with intravenous fluids and medical therapy including a short course of subcutaneous calcitonin, a total of 120 mg of denosumab and oral prednisolone. |
| format | Article |
| id | doaj-art-17f838ce9b3e4f3ab89949ef890f01ec |
| institution | Kabale University |
| issn | 2052-0573 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj-art-17f838ce9b3e4f3ab89949ef890f01ec2025-02-09T11:58:56ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732025-02-012025110.1530/EDM-24-011611,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reactionR K Dharmaputra0N Sheriff1S Ravichandran2Gold Coast University Hospital Department of Endocrinology, Southport, AustraliaGold Coast University Hospital Department of Endocrinology, Southport, AustraliaRoyal Darwin Hospital Department of Medicine, Darwin, AustraliaWe presented a case of a 72-year-old male with severe hypercalcaemia of 3.84 mmol/L following the second cycle of immunotherapy with ipilimumab and nivolumab in the setting of metastatic melanoma with known bone metastases. Further investigations demonstrated hilar lymphadenopathy, which was not present in previous imaging, and subsequent hypercalcaemia work-up demonstrated a significantly elevated serum calcitriol level as high as 429 pmol/L. A diagnosis of drug-induced sarcoid-like reactions or DISRs was made on the basis of hypercalcaemia and hilar lymphadenopathy following immunotherapy. Hypercalcaemia was effectively treated with intravenous fluids and medical therapy including a short course of subcutaneous calcitonin, a total of 120 mg of denosumab and oral prednisolone.https://edm.bioscientifica.com/view/journals/edm/2025/1/EDM-24-0116.xmlcalciumvitamin dcalcitriolsarcoidosishypercalcaemia |
| spellingShingle | R K Dharmaputra N Sheriff S Ravichandran 1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction Endocrinology, Diabetes & Metabolism Case Reports calcium vitamin d calcitriol sarcoidosis hypercalcaemia |
| title | 1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction |
| title_full | 1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction |
| title_fullStr | 1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction |
| title_full_unstemmed | 1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction |
| title_short | 1,25-Vitamin D-mediated hypercalcaemia in the setting of immune therapy-related sarcoid-like reaction |
| title_sort | 1 25 vitamin d mediated hypercalcaemia in the setting of immune therapy related sarcoid like reaction |
| topic | calcium vitamin d calcitriol sarcoidosis hypercalcaemia |
| url | https://edm.bioscientifica.com/view/journals/edm/2025/1/EDM-24-0116.xml |
| work_keys_str_mv | AT rkdharmaputra 125vitamindmediatedhypercalcaemiainthesettingofimmunetherapyrelatedsarcoidlikereaction AT nsheriff 125vitamindmediatedhypercalcaemiainthesettingofimmunetherapyrelatedsarcoidlikereaction AT sravichandran 125vitamindmediatedhypercalcaemiainthesettingofimmunetherapyrelatedsarcoidlikereaction |