It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia
We report a case of a syndrome first described by French bacteriologist André Lemierre nearly 100 years ago. A young woman presented with fever, chest pain and arthralgia. Admission investigations revealed thrombocytopenia, cavitating pneumonia and an internal jugular vein thrombus. Blood cultures w...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Clinical Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1470211824054459 |
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| author | Edmund Hugh Larkin Ana Garcia-Mingo Roopal Patel Andrew Badacsonyi |
| author_facet | Edmund Hugh Larkin Ana Garcia-Mingo Roopal Patel Andrew Badacsonyi |
| author_sort | Edmund Hugh Larkin |
| collection | DOAJ |
| description | We report a case of a syndrome first described by French bacteriologist André Lemierre nearly 100 years ago. A young woman presented with fever, chest pain and arthralgia. Admission investigations revealed thrombocytopenia, cavitating pneumonia and an internal jugular vein thrombus. Blood cultures were positive for Fusobacterium necrophorum and Streptococcus constellatus. Respiratory failure developed within 48 h and was managed with high-flow nasal oxygen in a critical care setting. The investigation findings leading to diagnosis, as well as the antimicrobial and anticoagulation management strategies, are discussed. Lemierre's syndrome is rarely encountered by non-specialists, but a good outcome can be expected with prompt diagnosis and treatment. |
| format | Article |
| id | doaj-art-17f82db557ce44469fc862ccd761064b |
| institution | DOAJ |
| issn | 1470-2118 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Medicine |
| spelling | doaj-art-17f82db557ce44469fc862ccd761064b2025-08-20T02:49:05ZengElsevierClinical Medicine1470-21182024-11-0124610026010.1016/j.clinme.2024.100260It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopeniaEdmund Hugh Larkin0Ana Garcia-Mingo1Roopal Patel2Andrew Badacsonyi3Intensive Care Unit, Whittington Health Trust, London, United Kingdom; Corresponding author.Infectious Diseases and Microbiology, Whittington Health Trust, London, United KingdomRadiology, Whittington Health Trust, London, United KingdomIntensive Care Unit, Whittington Health Trust, London, United KingdomWe report a case of a syndrome first described by French bacteriologist André Lemierre nearly 100 years ago. A young woman presented with fever, chest pain and arthralgia. Admission investigations revealed thrombocytopenia, cavitating pneumonia and an internal jugular vein thrombus. Blood cultures were positive for Fusobacterium necrophorum and Streptococcus constellatus. Respiratory failure developed within 48 h and was managed with high-flow nasal oxygen in a critical care setting. The investigation findings leading to diagnosis, as well as the antimicrobial and anticoagulation management strategies, are discussed. Lemierre's syndrome is rarely encountered by non-specialists, but a good outcome can be expected with prompt diagnosis and treatment.http://www.sciencedirect.com/science/article/pii/S1470211824054459Lemierre's syndromeFusobacterium necrophorumThrombophlebitis of the internal jugular veinCavitating lung lesionsThrombocytopenia |
| spellingShingle | Edmund Hugh Larkin Ana Garcia-Mingo Roopal Patel Andrew Badacsonyi It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia Clinical Medicine Lemierre's syndrome Fusobacterium necrophorum Thrombophlebitis of the internal jugular vein Cavitating lung lesions Thrombocytopenia |
| title | It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia |
| title_full | It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia |
| title_fullStr | It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia |
| title_full_unstemmed | It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia |
| title_short | It all started with a sore throat: Polymicrobial septicaemia, cavitating lung lesions and severe thrombocytopenia |
| title_sort | it all started with a sore throat polymicrobial septicaemia cavitating lung lesions and severe thrombocytopenia |
| topic | Lemierre's syndrome Fusobacterium necrophorum Thrombophlebitis of the internal jugular vein Cavitating lung lesions Thrombocytopenia |
| url | http://www.sciencedirect.com/science/article/pii/S1470211824054459 |
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