Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke
Abstract Background To investigate the effect of eosinophils on early (END) and delayed neurological deterioration (DND) after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS). Methods A total of 442 consecutive AIS patients experiencing MT between May 2017 and January 2023...
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BMC
2025-06-01
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| Online Access: | https://doi.org/10.1186/s12868-025-00954-8 |
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| author | Shuhong Yu Jinping Yang Xiaoting Han Jijun Shi Guodong Xiao Zhiliang Guo |
| author_facet | Shuhong Yu Jinping Yang Xiaoting Han Jijun Shi Guodong Xiao Zhiliang Guo |
| author_sort | Shuhong Yu |
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| description | Abstract Background To investigate the effect of eosinophils on early (END) and delayed neurological deterioration (DND) after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS). Methods A total of 442 consecutive AIS patients experiencing MT between May 2017 and January 2023 were analyzed. END and DND were defined as a rise of ≥ 2 points on the National Institutes of Health Stroke Scale (NIHSS) or a fall of ≥ 1 point on the Glasgow Coma Scale or death from baseline to 24 h and from 24 to 72 h, respectively. Multivariate regression analysis, generalize additive models and mediation analysis were used to assess the effect of eosinophils on END and DND and the underlying mechanisms. Results 113 (25.17%) and 47 (10.63%) patients had END and DND, respectively. Eosinophils was independently associated with END after adjusting potential confounders (odds ratio, 0.00; 95% CI, 0.00–0.80; P = 0.0441), which is consistent with the result of eosinophils (dichotomous) as a categorical variable (odds ratio, 0.40; 95% CI, 0.24–0.68; P = 0.0006). In assessing the relationship between eosinophils and DND, the inflection point was found to be 0.02, and eosinophils were independently correlated with DND at less than 0.02 (odds ratio, 0.00, 95% CI: 0.00–0.00, P = 0.0038); however, eosinophils ceased to be independently correlated with DND after exceeding 0.02 (P = 0.3519). Mediation analyses confirmed that eosinophils contribute to END in patients through symptomatic intracranial hemorrhage (indirect effect: -0.463; 95%CI: -0.902–0.19; P < 0.001). Conclusions The effects of eosinophils on END and DND are not identical. |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
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| series | BMC Neuroscience |
| spelling | doaj-art-17f6e2e576cb460fbd986dfc529ce4512025-08-20T02:05:46ZengBMCBMC Neuroscience1471-22022025-06-012611710.1186/s12868-025-00954-8Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in strokeShuhong Yu0Jinping Yang1Xiaoting Han2Jijun Shi3Guodong Xiao4Zhiliang Guo5Department of Encephalopathy, Suzhou Integrated Traditional Chinese and Western Medicine HospitalDepartment of Encephalopathy, Taicang TCM Hospital, Nanjing University of Chinese MedicineDepartment of Neurology, The Nuclear Industry 417 HospitalDepartment of Neurology, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurology, The Second Affiliated Hospital of Soochow UniversityAbstract Background To investigate the effect of eosinophils on early (END) and delayed neurological deterioration (DND) after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS). Methods A total of 442 consecutive AIS patients experiencing MT between May 2017 and January 2023 were analyzed. END and DND were defined as a rise of ≥ 2 points on the National Institutes of Health Stroke Scale (NIHSS) or a fall of ≥ 1 point on the Glasgow Coma Scale or death from baseline to 24 h and from 24 to 72 h, respectively. Multivariate regression analysis, generalize additive models and mediation analysis were used to assess the effect of eosinophils on END and DND and the underlying mechanisms. Results 113 (25.17%) and 47 (10.63%) patients had END and DND, respectively. Eosinophils was independently associated with END after adjusting potential confounders (odds ratio, 0.00; 95% CI, 0.00–0.80; P = 0.0441), which is consistent with the result of eosinophils (dichotomous) as a categorical variable (odds ratio, 0.40; 95% CI, 0.24–0.68; P = 0.0006). In assessing the relationship between eosinophils and DND, the inflection point was found to be 0.02, and eosinophils were independently correlated with DND at less than 0.02 (odds ratio, 0.00, 95% CI: 0.00–0.00, P = 0.0038); however, eosinophils ceased to be independently correlated with DND after exceeding 0.02 (P = 0.3519). Mediation analyses confirmed that eosinophils contribute to END in patients through symptomatic intracranial hemorrhage (indirect effect: -0.463; 95%CI: -0.902–0.19; P < 0.001). Conclusions The effects of eosinophils on END and DND are not identical.https://doi.org/10.1186/s12868-025-00954-8EosinophilsIschemic strokeMechanical thrombectomyNeurological deteriorationPrediction |
| spellingShingle | Shuhong Yu Jinping Yang Xiaoting Han Jijun Shi Guodong Xiao Zhiliang Guo Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke BMC Neuroscience Eosinophils Ischemic stroke Mechanical thrombectomy Neurological deterioration Prediction |
| title | Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke |
| title_full | Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke |
| title_fullStr | Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke |
| title_full_unstemmed | Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke |
| title_short | Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke |
| title_sort | eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke |
| topic | Eosinophils Ischemic stroke Mechanical thrombectomy Neurological deterioration Prediction |
| url | https://doi.org/10.1186/s12868-025-00954-8 |
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