Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2025-01-01
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| Series: | Disease Models & Mechanisms |
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| Online Access: | http://dmm.biologists.org/content/18/1/dmm050883 |
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| author | Haoyu Wu Annie S. P. Yang Suzan Stelloo Floris J. M. Roos René H. M. te Morsche Anne H. Verkerk Maria V. Luna-Velez Laura Wingens Johannes H. W. de Wilt Robert W. Sauerwein Klaas W. Mulder Simon J. van Heeringen Monique M. A. Verstegen Luc J. W. van der Laan Hendrik Marks Richárd Bártfai |
| author_facet | Haoyu Wu Annie S. P. Yang Suzan Stelloo Floris J. M. Roos René H. M. te Morsche Anne H. Verkerk Maria V. Luna-Velez Laura Wingens Johannes H. W. de Wilt Robert W. Sauerwein Klaas W. Mulder Simon J. van Heeringen Monique M. A. Verstegen Luc J. W. van der Laan Hendrik Marks Richárd Bártfai |
| author_sort | Haoyu Wu |
| collection | DOAJ |
| format | Article |
| id | doaj-art-17f615581e4848878bce56eb6907c502 |
| institution | Kabale University |
| issn | 1754-8403 1754-8411 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj-art-17f615581e4848878bce56eb6907c5022025-02-12T06:59:02ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112025-01-0118110.1242/dmm.050883050883Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytesHaoyu Wu0Annie S. P. Yang1Suzan Stelloo2Floris J. M. Roos3René H. M. te Morsche4Anne H. Verkerk5Maria V. Luna-Velez6Laura Wingens7Johannes H. W. de Wilt8Robert W. Sauerwein9Klaas W. Mulder10Simon J. van Heeringen11Monique M. A. Verstegen12Luc J. W. van der Laan13Hendrik Marks14Richárd Bártfai15 Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University, Nijmegen 6525GA, The Netherlands Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University, Nijmegen 6525GA, The Netherlands Department of Surgery, Erasmus University Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam 3000CA, The Netherlands Department of Gastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University, Nijmegen 6525GA, The Netherlands Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University, Nijmegen 6525GA, The Netherlands Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen 6525GA, The Netherlands Department of Surgery, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen 6500HB, The Netherlands Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen 6525GA, The Netherlands Department of Molecular Developmental Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen 6525GA, The Netherlands Department of Surgery, Erasmus University Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam 3000CA, The Netherlands Department of Surgery, Erasmus University Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam 3000CA, The Netherlands Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University, Nijmegen 6525GA, The Netherlands Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University, Nijmegen 6525GA, The Netherlands http://dmm.biologists.org/content/18/1/dmm050883intrahepatic cholangiocyte organoidsprimary human hepatocytesscrna-seqgene regulatory networkelf3 |
| spellingShingle | Haoyu Wu Annie S. P. Yang Suzan Stelloo Floris J. M. Roos René H. M. te Morsche Anne H. Verkerk Maria V. Luna-Velez Laura Wingens Johannes H. W. de Wilt Robert W. Sauerwein Klaas W. Mulder Simon J. van Heeringen Monique M. A. Verstegen Luc J. W. van der Laan Hendrik Marks Richárd Bártfai Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes Disease Models & Mechanisms intrahepatic cholangiocyte organoids primary human hepatocytes scrna-seq gene regulatory network elf3 |
| title | Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes |
| title_full | Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes |
| title_fullStr | Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes |
| title_full_unstemmed | Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes |
| title_short | Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes |
| title_sort | multi omics analysis reveals distinct gene regulatory mechanisms between primary and organoid derived human hepatocytes |
| topic | intrahepatic cholangiocyte organoids primary human hepatocytes scrna-seq gene regulatory network elf3 |
| url | http://dmm.biologists.org/content/18/1/dmm050883 |
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