Study of the Immunological Status of Iraqi Vitiligo Patients
Vitiligo is an acquired idiopathic skin disorder characterized by depigmented macules due to loss of cutaneous melanocytes. A potential role of the immune dysfunction has been suggested in vitiligo, so to test this hypothesis, certain cytokines (IL-17A and TNF-?) and immunoglobulins (IgM, IgG, IgA a...
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University of Baghdad, College of Science for Women
2016-09-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2290 |
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| description | Vitiligo is an acquired idiopathic skin disorder characterized by depigmented macules due to loss of cutaneous melanocytes. A potential role of the immune dysfunction has been suggested in vitiligo, so to test this hypothesis, certain cytokines (IL-17A and TNF-?) and immunoglobulins (IgM, IgG, IgA and total IgE) were investigated in all participants. The study included: 60 patients with age range between (6-55) year; 30(11 males and 19 females) were untreated and 30(12 males and 18 females) were treated with Narrow Band Ultraviolet-B (NB-UVB) and 30 (14 males and 16 females) apparently healthy control. Serum was separated and cytokines (IL-17A and TNF-?) and total immunoglobulin E (IgE) were detected by using Enzyme Linked Immunosorbent Assay (ELISA); while immunoglobulins (IgM, IgG and IgA) were detected by using Single Radial Immunodiffusion (SRID) method. The results showed that the mean levels of serum IL-17A and TNF-? in both untreated and NB-UVB treated vitiligo patients were increased significantly (p ? 0.05) as compared with healthy control. The mean levels of serum IgG and IgA in untreated vitiligo patients showed non significant decreased (P |
| format | Article |
| id | doaj-art-17f26c14e22741138bbdf56942e1ef96 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-17f26c14e22741138bbdf56942e1ef962025-08-20T03:33:27ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862016-09-0113310.21123/bsj.13.3.454-462Study of the Immunological Status of Iraqi Vitiligo PatientsBaghdad Science JournalVitiligo is an acquired idiopathic skin disorder characterized by depigmented macules due to loss of cutaneous melanocytes. A potential role of the immune dysfunction has been suggested in vitiligo, so to test this hypothesis, certain cytokines (IL-17A and TNF-?) and immunoglobulins (IgM, IgG, IgA and total IgE) were investigated in all participants. The study included: 60 patients with age range between (6-55) year; 30(11 males and 19 females) were untreated and 30(12 males and 18 females) were treated with Narrow Band Ultraviolet-B (NB-UVB) and 30 (14 males and 16 females) apparently healthy control. Serum was separated and cytokines (IL-17A and TNF-?) and total immunoglobulin E (IgE) were detected by using Enzyme Linked Immunosorbent Assay (ELISA); while immunoglobulins (IgM, IgG and IgA) were detected by using Single Radial Immunodiffusion (SRID) method. The results showed that the mean levels of serum IL-17A and TNF-? in both untreated and NB-UVB treated vitiligo patients were increased significantly (p ? 0.05) as compared with healthy control. The mean levels of serum IgG and IgA in untreated vitiligo patients showed non significant decreased (Phttp://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2290"Vitiligo, IL-17A, TNF- ?, Immunoglobulins" |
| spellingShingle | Baghdad Science Journal Study of the Immunological Status of Iraqi Vitiligo Patients مجلة بغداد للعلوم "Vitiligo, IL-17A, TNF- ?, Immunoglobulins" |
| title | Study of the Immunological Status of Iraqi Vitiligo Patients |
| title_full | Study of the Immunological Status of Iraqi Vitiligo Patients |
| title_fullStr | Study of the Immunological Status of Iraqi Vitiligo Patients |
| title_full_unstemmed | Study of the Immunological Status of Iraqi Vitiligo Patients |
| title_short | Study of the Immunological Status of Iraqi Vitiligo Patients |
| title_sort | study of the immunological status of iraqi vitiligo patients |
| topic | "Vitiligo, IL-17A, TNF- ?, Immunoglobulins" |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2290 |
| work_keys_str_mv | AT baghdadsciencejournal studyoftheimmunologicalstatusofiraqivitiligopatients |