Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study
IntroductionElectroencephalographic (EEG) abnormalities, such as increased theta power, have been proposed as biomarkers for neurocognitive disorders. Advancements in amyloid positron emission tomography (PET) imaging have enhanced our understanding of the pathology of neurocognitive disorders, such...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1510878/full |
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| author | Jaesub Park Jaesub Park Woo Jung Kim Woo Jung Kim Han Wool Jung Han Wool Jung Jae-Jin Kim Jae-Jin Kim Jin Young Park Jin Young Park Jin Young Park |
| author_facet | Jaesub Park Jaesub Park Woo Jung Kim Woo Jung Kim Han Wool Jung Han Wool Jung Jae-Jin Kim Jae-Jin Kim Jin Young Park Jin Young Park Jin Young Park |
| author_sort | Jaesub Park |
| collection | DOAJ |
| description | IntroductionElectroencephalographic (EEG) abnormalities, such as increased theta power, have been proposed as biomarkers for neurocognitive disorders. Advancements in amyloid positron emission tomography (PET) imaging have enhanced our understanding of the pathology of neurocognitive disorders, such as amyloid deposition. However, much remains unknown regarding the relationship between regional amyloid deposition and EEG abnormalities. This study aimed to explore the relationship between regional EEG abnormalities and amyloid deposition in patients with mild cognitive impairment (MCI).MethodsWe recruited 24 older adults with MCI from a community center for dementia prevention, and 21 participants were included in the final analysis. EEG was recorded using a 64-channel system, and amyloid deposition was measured using amyloid PET imaging. Magnetic resonance imaging (MRI) data were used to create individualized brain models for EEG source localization. Correlations between relative theta power and standardized uptake value ratios (SUVRs) in 12 brain regions were analyzed using Spearman’s correlation coefficient.ResultsSignificant positive correlations between relative theta power and SUVR values were found in several brain regions in the individualized brain model during the resting eyes-closed condition, including right temporal lobe (r = 0.581, p = 0.006), left hippocampus (r = 0.438, p = 0.047), left parietal lobe (r = 0.471, p = 0.031), right parietal lobe (r = 0.509, p = 0.018), left occipital lobe (r = 0.597, p = 0.004), and right occipital lobe (r = 0.590, p = 0.005). During the visual working memory condition, significant correlations were found in both cingulate lobes (left: r = 0.483, p = 0.027; right: r = 0.449, p = 0.041), left parietal lobe (r = 0.530, p = 0.010), right parietal lobe (r = 0.606, p = 0.004), left occipital lobe (r = 0.648, p = 0.001), and right occipital lobe (r = 0.657, p = 0.001).ConclusionThe result suggests that regional increases in relative theta power are associated with regional amyloid deposition in patients with MCI. These findings highlight the potential of EEG in detecting amyloid deposition. Future large-scale studies are needed to validate these preliminary findings and explore their clinical applications. |
| format | Article |
| id | doaj-art-17f0cf6814334a3c863f2cc882336ab5 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-17f0cf6814334a3c863f2cc882336ab52025-02-07T06:49:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.15108781510878Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory studyJaesub Park0Jaesub Park1Woo Jung Kim2Woo Jung Kim3Han Wool Jung4Han Wool Jung5Jae-Jin Kim6Jae-Jin Kim7Jin Young Park8Jin Young Park9Jin Young Park10Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi, Republic of KoreaInstitute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi, Republic of KoreaInstitute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi, Republic of KoreaInstitute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaInstitute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Gyeonggi, Republic of KoreaInstitute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of KoreaCenter for Digital Health, Yongin Severance Hospital, Yonsei University Health System, Yongin, Gyeonggi, Republic of KoreaIntroductionElectroencephalographic (EEG) abnormalities, such as increased theta power, have been proposed as biomarkers for neurocognitive disorders. Advancements in amyloid positron emission tomography (PET) imaging have enhanced our understanding of the pathology of neurocognitive disorders, such as amyloid deposition. However, much remains unknown regarding the relationship between regional amyloid deposition and EEG abnormalities. This study aimed to explore the relationship between regional EEG abnormalities and amyloid deposition in patients with mild cognitive impairment (MCI).MethodsWe recruited 24 older adults with MCI from a community center for dementia prevention, and 21 participants were included in the final analysis. EEG was recorded using a 64-channel system, and amyloid deposition was measured using amyloid PET imaging. Magnetic resonance imaging (MRI) data were used to create individualized brain models for EEG source localization. Correlations between relative theta power and standardized uptake value ratios (SUVRs) in 12 brain regions were analyzed using Spearman’s correlation coefficient.ResultsSignificant positive correlations between relative theta power and SUVR values were found in several brain regions in the individualized brain model during the resting eyes-closed condition, including right temporal lobe (r = 0.581, p = 0.006), left hippocampus (r = 0.438, p = 0.047), left parietal lobe (r = 0.471, p = 0.031), right parietal lobe (r = 0.509, p = 0.018), left occipital lobe (r = 0.597, p = 0.004), and right occipital lobe (r = 0.590, p = 0.005). During the visual working memory condition, significant correlations were found in both cingulate lobes (left: r = 0.483, p = 0.027; right: r = 0.449, p = 0.041), left parietal lobe (r = 0.530, p = 0.010), right parietal lobe (r = 0.606, p = 0.004), left occipital lobe (r = 0.648, p = 0.001), and right occipital lobe (r = 0.657, p = 0.001).ConclusionThe result suggests that regional increases in relative theta power are associated with regional amyloid deposition in patients with MCI. These findings highlight the potential of EEG in detecting amyloid deposition. Future large-scale studies are needed to validate these preliminary findings and explore their clinical applications.https://www.frontiersin.org/articles/10.3389/fnins.2025.1510878/fullsource localizationamyloid PET imagingEEG theta powermild cognitive impairment (MCI)regional brain activityAlzheimer’s disease biomarkers |
| spellingShingle | Jaesub Park Jaesub Park Woo Jung Kim Woo Jung Kim Han Wool Jung Han Wool Jung Jae-Jin Kim Jae-Jin Kim Jin Young Park Jin Young Park Jin Young Park Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study Frontiers in Neuroscience source localization amyloid PET imaging EEG theta power mild cognitive impairment (MCI) regional brain activity Alzheimer’s disease biomarkers |
| title | Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study |
| title_full | Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study |
| title_fullStr | Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study |
| title_full_unstemmed | Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study |
| title_short | Relationship between regional relative theta power and amyloid deposition in mild cognitive impairment: an exploratory study |
| title_sort | relationship between regional relative theta power and amyloid deposition in mild cognitive impairment an exploratory study |
| topic | source localization amyloid PET imaging EEG theta power mild cognitive impairment (MCI) regional brain activity Alzheimer’s disease biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1510878/full |
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