Interleukin-1α deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice

Interleukin-1α deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice

Objective While extensive research revealed that interleukin (IL)-1β contributes to insulin resistance (IR) development, the role of IL-1α in obesity and IR was scarcely studied. Using control, whole body IL-1α knockout (KO) or myeloid-cell-specific IL-1α-deficient mice, we tested the hypothesis tha...

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Main Authors: Tal Almog, Michal Kandel Kfir, Hana Levkovich, Gadi Shlomai, Iris Barshack, Rinke Stienstra, Yaniv Lustig, Alicia Leikin Frenkel, Ayelet Harari, Yoram Bujanover, Roni Apte, Aviv Shaish, Dror Harats, Yehuda Kamari
Format: Article
Language:English
Published: BMJ Publishing Group 2019-05-01
Series:BMJ Open Diabetes Research & Care
Online Access:https://drc.bmj.com/content/7/1/e000650.full
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