The Engrailed-1 Gene Stimulates Brown Adipogenesis
As a thermogenic organ, brown adipose tissue (BAT) has received a great attention in treating obesity and related diseases. It has been reported that brown adipocyte was derived from engrailed-1 (EN1) positive central dermomyotome. However, functions of EN1 in brown adipogenesis are largely unknown....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/7369491 |
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| _version_ | 1850235028187906048 |
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| author | Chuanhai Zhang Yibing Weng Fangxiong Shi Wanzhu Jin |
| author_facet | Chuanhai Zhang Yibing Weng Fangxiong Shi Wanzhu Jin |
| author_sort | Chuanhai Zhang |
| collection | DOAJ |
| description | As a thermogenic organ, brown adipose tissue (BAT) has received a great attention in treating obesity and related diseases. It has been reported that brown adipocyte was derived from engrailed-1 (EN1) positive central dermomyotome. However, functions of EN1 in brown adipogenesis are largely unknown. Here we demonstrated that EN1 overexpression increased while EN1 knockdown decreased lipid accumulation and the expressions of key adipogenic genes including PPARγ2 and C/EBPα and mitochondrial OXPHOS as well as BAT specific marker UCP1. Taken together, our findings clearly indicate that EN1 is a positive regulator of brown adipogenesis. |
| format | Article |
| id | doaj-art-17e82c7b756a42d6a30a0ede4cea7235 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-17e82c7b756a42d6a30a0ede4cea72352025-08-20T02:02:26ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/73694917369491The Engrailed-1 Gene Stimulates Brown AdipogenesisChuanhai Zhang0Yibing Weng1Fangxiong Shi2Wanzhu Jin3Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaDepartment of Critical Care Medicine and Emergency Room, Luhe Hospital, Capital Medical University, Beijing 101149, ChinaLaboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaAs a thermogenic organ, brown adipose tissue (BAT) has received a great attention in treating obesity and related diseases. It has been reported that brown adipocyte was derived from engrailed-1 (EN1) positive central dermomyotome. However, functions of EN1 in brown adipogenesis are largely unknown. Here we demonstrated that EN1 overexpression increased while EN1 knockdown decreased lipid accumulation and the expressions of key adipogenic genes including PPARγ2 and C/EBPα and mitochondrial OXPHOS as well as BAT specific marker UCP1. Taken together, our findings clearly indicate that EN1 is a positive regulator of brown adipogenesis.http://dx.doi.org/10.1155/2016/7369491 |
| spellingShingle | Chuanhai Zhang Yibing Weng Fangxiong Shi Wanzhu Jin The Engrailed-1 Gene Stimulates Brown Adipogenesis Stem Cells International |
| title | The Engrailed-1 Gene Stimulates Brown Adipogenesis |
| title_full | The Engrailed-1 Gene Stimulates Brown Adipogenesis |
| title_fullStr | The Engrailed-1 Gene Stimulates Brown Adipogenesis |
| title_full_unstemmed | The Engrailed-1 Gene Stimulates Brown Adipogenesis |
| title_short | The Engrailed-1 Gene Stimulates Brown Adipogenesis |
| title_sort | engrailed 1 gene stimulates brown adipogenesis |
| url | http://dx.doi.org/10.1155/2016/7369491 |
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