The sequence 581Ser-610Val in the fibrinogen Aα chain is responsible for the formation of complexes between plasminogen and αC-regions of fibrin(ogen)

The sequence 581Ser-610Val in the fibrinogen Aα chain is responsible for the formation of complexes between plasminogen and αC-regions of fibrin(ogen)

Objective: This study aimed to identify the binding sites for plasminogen (Pg) and its kringle-containing fragments within the αC-region of fibrin(ogen). This investigation is crucial while the conversion of fibrinogen into fibrin induces conformational changes that expose binding sites for Pg and t...

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Bibliographic Details
Main Authors: Lada Kapustianenko, Tetiana Grinenko, Andrew Rebriev, Artem Tykhomyrov
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Plasminogen
Kringle fragments
tPA
Fibrin(ogen)
αC-region
MALDI-TOF mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024168831
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