Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults

Abstract Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms. Therefore, the main objective of this study was to explore how sleep difficu...

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Main Authors: Yaoyao Wu, Zesheng Chen, Zongxue Cheng, Zhecong Yu, Kang Qin, Caixia Jiang, Jue Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-86420-1
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author Yaoyao Wu
Zesheng Chen
Zongxue Cheng
Zhecong Yu
Kang Qin
Caixia Jiang
Jue Xu
author_facet Yaoyao Wu
Zesheng Chen
Zongxue Cheng
Zhecong Yu
Kang Qin
Caixia Jiang
Jue Xu
author_sort Yaoyao Wu
collection DOAJ
description Abstract Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms. Therefore, the main objective of this study was to explore how sleep difficulty mediates the impact of chronic diseases on the HRQoL of middle-aged and older adults. The survey data were from a cross-sectional study carried out in 2019 in Hangzhou, China. We used a multi-stage cluster random sampling method to recruit participants from seven districts in Hangzhou. Multiple regression was used to analyze the relationship between chronic diseases, sleep difficulty and HRQoL. And the mediate package in the R language was used to analyze the mediating effect. A total of 3,550 middle-aged and older adults were enrolled, including 2,273 patients with chronic diseases and 1,277 patients without them. Patients with chronic diseases had lower health utility values (β=-0.0084, P < 0.01) and were more likely to suffer from sleep difficulty (β = 0.5737, P < 0.001). After correcting for demographic and life characteristics, the mediation analysis results indicated that sleep difficulty mediated the relationship between chronic diseases and HRQoL (β=-0.0022, 95% Bca CI: -0.0034 -0.0014). Additionally, sleep difficulty influenced the association between chronic diseases and daily activities as well as pain (or discomfort) (β = 0.0083, 95% Bca CI: 0.0042–0.0111; β = 0.0162, 95% Bca CI: 0.0107–0.0225) in the analysis of the dimensions. Sleep difficulty partially mediated the relationship between chronic diseases and HRQoL, and primarily in the daily activities and pain (or discomfort) dimensions in middle-aged and older adults.
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spelling doaj-art-17df28c50ace4bc8be8d0d8bdfa1a46f2025-01-26T12:24:03ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-86420-1Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adultsYaoyao Wu0Zesheng Chen1Zongxue Cheng2Zhecong Yu3Kang Qin4Caixia Jiang5Jue Xu6Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution)Abstract Middle-aged and older adults with chronic diseases are more likely to encounter sleep difficulty and have a reduced Health-Related Quality of Life (HRQoL), but there is little research on their possible mechanisms. Therefore, the main objective of this study was to explore how sleep difficulty mediates the impact of chronic diseases on the HRQoL of middle-aged and older adults. The survey data were from a cross-sectional study carried out in 2019 in Hangzhou, China. We used a multi-stage cluster random sampling method to recruit participants from seven districts in Hangzhou. Multiple regression was used to analyze the relationship between chronic diseases, sleep difficulty and HRQoL. And the mediate package in the R language was used to analyze the mediating effect. A total of 3,550 middle-aged and older adults were enrolled, including 2,273 patients with chronic diseases and 1,277 patients without them. Patients with chronic diseases had lower health utility values (β=-0.0084, P < 0.01) and were more likely to suffer from sleep difficulty (β = 0.5737, P < 0.001). After correcting for demographic and life characteristics, the mediation analysis results indicated that sleep difficulty mediated the relationship between chronic diseases and HRQoL (β=-0.0022, 95% Bca CI: -0.0034 -0.0014). Additionally, sleep difficulty influenced the association between chronic diseases and daily activities as well as pain (or discomfort) (β = 0.0083, 95% Bca CI: 0.0042–0.0111; β = 0.0162, 95% Bca CI: 0.0107–0.0225) in the analysis of the dimensions. Sleep difficulty partially mediated the relationship between chronic diseases and HRQoL, and primarily in the daily activities and pain (or discomfort) dimensions in middle-aged and older adults.https://doi.org/10.1038/s41598-025-86420-1Chronic diseasesHealth-related quality of lifeSleep difficultyDaily activitiesPain/Discomfort
spellingShingle Yaoyao Wu
Zesheng Chen
Zongxue Cheng
Zhecong Yu
Kang Qin
Caixia Jiang
Jue Xu
Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
Scientific Reports
Chronic diseases
Health-related quality of life
Sleep difficulty
Daily activities
Pain/Discomfort
title Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
title_full Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
title_fullStr Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
title_full_unstemmed Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
title_short Effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
title_sort effects of chronic diseases on health related quality of life is mediated by sleep difficulty in middle aged and older adults
topic Chronic diseases
Health-related quality of life
Sleep difficulty
Daily activities
Pain/Discomfort
url https://doi.org/10.1038/s41598-025-86420-1
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