Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists
Liver tissue-resident memory T (TRM) cells play a pivotal role in hepatic immune responses. Their unique residence within liver sinusoids allow continuous antigen surveillance. In this review, we highlight the role of liver TRM cells in protective immunity and disease pathology. Comparisons between...
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Gastroenterology Council for Gut and Liver
2025-03-01
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| Series: | Gut and Liver |
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| Online Access: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl240366 |
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| author | Ji Won Han Eui-Cheol Shin |
| author_facet | Ji Won Han Eui-Cheol Shin |
| author_sort | Ji Won Han |
| collection | DOAJ |
| description | Liver tissue-resident memory T (TRM) cells play a pivotal role in hepatic immune responses. Their unique residence within liver sinusoids allow continuous antigen surveillance. In this review, we highlight the role of liver TRM cells in protective immunity and disease pathology. Comparisons between human and murine liver TRM cells reveal species-specific characteristics, suggesting the need for human-focused studies. One key finding is the involvement of liver TRM cells in viral hepatitis, where they can both control infection and contribute to liver damage. Liver TRM cells also exhibit dual roles in metabolic-associated steatotic liver disease, promoting inflammation and fibrosis while also contributing to fibrosis resolution. In autoimmune liver diseases, such as autoimmune hepatitis and primary sclerosing cholangitis, the presence of liver TRM cells correlates with disease severity. In this review, we underscore the importance of liver TRM cells in vaccine development, particularly vaccines against malaria. Future research should focus on the mechanisms governing TRM-cell formation, maintenance, and function, with the aim of supporting their protective roles while mitigating detrimental effects. Advancing our understanding of liver TRM cells will enhance our knowledge of liver immunology and inform novel therapeutic strategies for liver disease management. |
| format | Article |
| id | doaj-art-17da661cf4174dcaa73e70a9893387e4 |
| institution | OA Journals |
| issn | 1976-2283 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Gastroenterology Council for Gut and Liver |
| record_format | Article |
| series | Gut and Liver |
| spelling | doaj-art-17da661cf4174dcaa73e70a9893387e42025-08-20T02:06:28ZengGastroenterology Council for Gut and LiverGut and Liver1976-22832025-03-0119216117010.5009/gnl240366gnl240366Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and HepatologistsJi Won Han0Eui-Cheol Shin1The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, Seoul, KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, KoreaLiver tissue-resident memory T (TRM) cells play a pivotal role in hepatic immune responses. Their unique residence within liver sinusoids allow continuous antigen surveillance. In this review, we highlight the role of liver TRM cells in protective immunity and disease pathology. Comparisons between human and murine liver TRM cells reveal species-specific characteristics, suggesting the need for human-focused studies. One key finding is the involvement of liver TRM cells in viral hepatitis, where they can both control infection and contribute to liver damage. Liver TRM cells also exhibit dual roles in metabolic-associated steatotic liver disease, promoting inflammation and fibrosis while also contributing to fibrosis resolution. In autoimmune liver diseases, such as autoimmune hepatitis and primary sclerosing cholangitis, the presence of liver TRM cells correlates with disease severity. In this review, we underscore the importance of liver TRM cells in vaccine development, particularly vaccines against malaria. Future research should focus on the mechanisms governing TRM-cell formation, maintenance, and function, with the aim of supporting their protective roles while mitigating detrimental effects. Advancing our understanding of liver TRM cells will enhance our knowledge of liver immunology and inform novel therapeutic strategies for liver disease management.http://gutnliver.org/journal/view.html?doi=10.5009/gnl240366t-lymphocytestissue resident t cellliver diseases |
| spellingShingle | Ji Won Han Eui-Cheol Shin Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists Gut and Liver t-lymphocytes tissue resident t cell liver diseases |
| title | Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists |
| title_full | Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists |
| title_fullStr | Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists |
| title_full_unstemmed | Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists |
| title_short | Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists |
| title_sort | investigating human liver tissue resident memory t cells from the perspectives of gastroenterologists and hepatologists |
| topic | t-lymphocytes tissue resident t cell liver diseases |
| url | http://gutnliver.org/journal/view.html?doi=10.5009/gnl240366 |
| work_keys_str_mv | AT jiwonhan investigatinghumanlivertissueresidentmemorytcellsfromtheperspectivesofgastroenterologistsandhepatologists AT euicheolshin investigatinghumanlivertissueresidentmemorytcellsfromtheperspectivesofgastroenterologistsandhepatologists |