Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment
Regulated negative pressure-assisted wound therapy (RNPT) should be regarded as a state-of-the-art technology in wound treatment and the most important physical, nonpharmaceutical, platform technology developed and applied for wound healing in the last two decades. RNPT systems maintain the treated...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2012-05-01
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| Series: | Indian Journal of Plastic Surgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.101301 |
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| author | Moris Topaz |
| author_facet | Moris Topaz |
| author_sort | Moris Topaz |
| collection | DOAJ |
| description | Regulated negative pressure-assisted wound therapy (RNPT) should be regarded as a state-of-the-art technology in wound treatment and the most important physical, nonpharmaceutical, platform technology developed and applied for wound healing in the last two decades. RNPT systems maintain the treated wound′s environment as a semi-closed, semi-isolated system applying external physical stimulations to the wound, leading to biological and biochemical effects, with the potential to substantially influence wound-host interactions, and when properly applied may enhance wound healing. RNPT is a simple, safe, and affordable tool that can be utilized in a wide range of acute and chronic conditions, with reduced need for complicated surgical procedures, and antibiotic treatment. This technology has been shown to be effective and safe, saving limbs and lives on a global scale. Regulated, oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) is an innovative technology, whereby supplemental oxygen is concurrently administered with RNPT for their synergistic effect on treatment and prophylaxis of anaerobic wound infection and promotion of wound healing. Understanding the basic science, modes of operation and the associated risks of these technologies through their fundamental clinical mechanisms is the main objective of this review. |
| format | Article |
| id | doaj-art-17d89ecc51e64dc285c7a00602dbdf29 |
| institution | DOAJ |
| issn | 0970-0358 1998-376X |
| language | English |
| publishDate | 2012-05-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Plastic Surgery |
| spelling | doaj-art-17d89ecc51e64dc285c7a00602dbdf292025-08-20T03:17:03ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Plastic Surgery0970-03581998-376X2012-05-01450229130110.4103/0970-0358.101301Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessmentMoris Topaz0Plastic Surgery Unit, Hillel Yaffe Medical Center, Hadera, Department of Chemistry, Bar Ilan University, Ramat GanRegulated negative pressure-assisted wound therapy (RNPT) should be regarded as a state-of-the-art technology in wound treatment and the most important physical, nonpharmaceutical, platform technology developed and applied for wound healing in the last two decades. RNPT systems maintain the treated wound′s environment as a semi-closed, semi-isolated system applying external physical stimulations to the wound, leading to biological and biochemical effects, with the potential to substantially influence wound-host interactions, and when properly applied may enhance wound healing. RNPT is a simple, safe, and affordable tool that can be utilized in a wide range of acute and chronic conditions, with reduced need for complicated surgical procedures, and antibiotic treatment. This technology has been shown to be effective and safe, saving limbs and lives on a global scale. Regulated, oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) is an innovative technology, whereby supplemental oxygen is concurrently administered with RNPT for their synergistic effect on treatment and prophylaxis of anaerobic wound infection and promotion of wound healing. Understanding the basic science, modes of operation and the associated risks of these technologies through their fundamental clinical mechanisms is the main objective of this review.http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.101301regulated negative pressure-assisted wound therapyregulatedoxygen-enriched negative pressure-assisted wound therapyvacuumwound healing |
| spellingShingle | Moris Topaz Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment Indian Journal of Plastic Surgery regulated negative pressure-assisted wound therapy regulated oxygen-enriched negative pressure-assisted wound therapy vacuum wound healing |
| title | Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment |
| title_full | Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment |
| title_fullStr | Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment |
| title_full_unstemmed | Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment |
| title_short | Improved wound management by regulated negative pressure-assisted wound therapy and regulated, oxygen- enriched negative pressure-assisted wound therapy through basic science research and clinical assessment |
| title_sort | improved wound management by regulated negative pressure assisted wound therapy and regulated oxygen enriched negative pressure assisted wound therapy through basic science research and clinical assessment |
| topic | regulated negative pressure-assisted wound therapy regulated oxygen-enriched negative pressure-assisted wound therapy vacuum wound healing |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.101301 |
| work_keys_str_mv | AT moristopaz improvedwoundmanagementbyregulatednegativepressureassistedwoundtherapyandregulatedoxygenenrichednegativepressureassistedwoundtherapythroughbasicscienceresearchandclinicalassessment |