Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification
Purpose: to determine the clinical efficacy of a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan) in the correction of secondary dry eye syndrome (DES) manifestations in patients after cataract phacoemulsification (CPE), based on monitoring clinical and functional characteristics of t...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2020-03-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/377 |
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| author | O. I. Lebedev A. V. Surov Ye. V. Akentyeva G. M. Kozachenko O. E. Shkutovich S. Y. Trenina I. A. Svinareva |
| author_facet | O. I. Lebedev A. V. Surov Ye. V. Akentyeva G. M. Kozachenko O. E. Shkutovich S. Y. Trenina I. A. Svinareva |
| author_sort | O. I. Lebedev |
| collection | DOAJ |
| description | Purpose: to determine the clinical efficacy of a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan) in the correction of secondary dry eye syndrome (DES) manifestations in patients after cataract phacoemulsification (CPE), based on monitoring clinical and functional characteristics of the ocular surface. Materials and methods. 62 patients with immature cataracts underwent CPE with IOL implantation. Special examination techniques (Schirmer's test, Norn test, assessment of conjunctival hyperemia on the ORA scale (Ocular Redness Analysis)) were performed before the operation, 7 days and 30 days after it. The main group of patients (31 patients) received, in addition to the standard postoperative treatment, a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan), whilst the control group (31 patients) received standard therapy. Results. The parameters studied showed a significant worsening in patients of both groups by the 7 th day after surgery, with no statistically significant difference between the groups. 30 days after CPE, the values of the Schirmer I test in the main group increased from 7.4 ± 2.3 mm (7 days after surgery) to 12.6 ± 1.7 mm, which significantly exceeded the respective values in patients of the control group: from 7.2 ± 2.1 mm (7 days after surgery) to 8.7 ± 2.0 mm (p < 0.001). Norn test scores also increased from 4.3 ± 1.9 s (7 days after surgery) to 7.9 ± 1.3 s in the main group and from 4.1 ± 2.1 s (7 days after the operation) to 5.3 ± 1.2 s in the control group with a statistically significant difference between the groups (p < 0.001). Conclusions. The use of a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan) as part of combined therapy after CPE helps to effectively reduce the main manifestations of dry eye syndrome and improves postoperative rehabilitation. |
| format | Article |
| id | doaj-art-17d7306e9d294fac987dc779a79aab3e |
| institution | DOAJ |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-17d7306e9d294fac987dc779a79aab3e2025-08-20T02:54:10ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602020-03-01131354110.21516/2072-0076-2020-13-1-35-41261Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsificationO. I. Lebedev0A. V. Surov1Ye. V. Akentyeva2G. M. Kozachenko3O. E. Shkutovich4S. Y. Trenina5I. A. Svinareva6Omsk State Medical UniversityOmsk State Medical UniversityClinical Ophthalmologic Hospital named after V.P. VykhodtsevClinical Ophthalmologic Hospital named after V.P. VykhodtsevState Public Association City Polyclinic No. 10Omsk State Medical UniversityOmsk State Medical UniversityPurpose: to determine the clinical efficacy of a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan) in the correction of secondary dry eye syndrome (DES) manifestations in patients after cataract phacoemulsification (CPE), based on monitoring clinical and functional characteristics of the ocular surface. Materials and methods. 62 patients with immature cataracts underwent CPE with IOL implantation. Special examination techniques (Schirmer's test, Norn test, assessment of conjunctival hyperemia on the ORA scale (Ocular Redness Analysis)) were performed before the operation, 7 days and 30 days after it. The main group of patients (31 patients) received, in addition to the standard postoperative treatment, a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan), whilst the control group (31 patients) received standard therapy. Results. The parameters studied showed a significant worsening in patients of both groups by the 7 th day after surgery, with no statistically significant difference between the groups. 30 days after CPE, the values of the Schirmer I test in the main group increased from 7.4 ± 2.3 mm (7 days after surgery) to 12.6 ± 1.7 mm, which significantly exceeded the respective values in patients of the control group: from 7.2 ± 2.1 mm (7 days after surgery) to 8.7 ± 2.0 mm (p < 0.001). Norn test scores also increased from 4.3 ± 1.9 s (7 days after surgery) to 7.9 ± 1.3 s in the main group and from 4.1 ± 2.1 s (7 days after the operation) to 5.3 ± 1.2 s in the control group with a statistically significant difference between the groups (p < 0.001). Conclusions. The use of a non-preservative drug based on sodium hyaluronate 0.3 % (Gilan) as part of combined therapy after CPE helps to effectively reduce the main manifestations of dry eye syndrome and improves postoperative rehabilitation.https://roj.igb.ru/jour/article/view/377sodium hyaluronatedry eye syndromephacoemulsification |
| spellingShingle | O. I. Lebedev A. V. Surov Ye. V. Akentyeva G. M. Kozachenko O. E. Shkutovich S. Y. Trenina I. A. Svinareva Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification Российский офтальмологический журнал sodium hyaluronate dry eye syndrome phacoemulsification |
| title | Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification |
| title_full | Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification |
| title_fullStr | Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification |
| title_full_unstemmed | Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification |
| title_short | Evaluation of efficacy of hyaluronic acid preservative-free preparation 0.3 % in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification |
| title_sort | evaluation of efficacy of hyaluronic acid preservative free preparation 0 3 in the prevention of secondary dry eye syndrome in patients after cataract phacoemulsification |
| topic | sodium hyaluronate dry eye syndrome phacoemulsification |
| url | https://roj.igb.ru/jour/article/view/377 |
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