Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age
BackgroundDeceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS.MethodsA tota...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1495129/full |
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| author | Jijing Wang Jinyi Xu Yanyan Qiu Ruike Yang Wentao Wang Chuanyu Gao Chuanyu Gao |
| author_facet | Jijing Wang Jinyi Xu Yanyan Qiu Ruike Yang Wentao Wang Chuanyu Gao Chuanyu Gao |
| author_sort | Jijing Wang |
| collection | DOAJ |
| description | BackgroundDeceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS.MethodsA total of 94 consecutive patients with VVS [51.0 (38.0–60.0) years; 48 males] and 76 healthy subjects [53.0 (44.3–62.8) years; 46 males] were recruited as controls. The study compared DC, AC, and heart rate variability (HRV) in 24-h ECG, echocardiogram, and biochemical examinations between the two groups.ResultsDC was significantly higher (9.3 ± 2.1 vs. 7.4 ± 1.4 ms, p < .001) and AC was lower (−9.3 ± 2.1 vs. −7.3 ± 1.3 ms, p < .001) in the syncope group compared to the control group. HRV indicators were higher in the syncope group. In multivariable analyses, DC [odds ratio = 1.746 (95% CI, 1.389–2.195); p < .001], AC [odds ratio = 0.553 (95% CI, 0.435–0.702); p < .001] were independently associated with syncope. Mean HR was associated with syncope only in patients <60 years of age. Receiver operating characteristics (ROC) curves showed areas under curve (AUC) of DC/AC for predicting syncope are 0.755/0.765 with sensitivity of 56.4%/60.6% and specificity of 93.4%/88.2%.ConclusionPatients with VVS exhibit higher DC and lower AC. Both DC and AC are independently correlated with syncope. A DC value >9.0 ms and an AC value −9.0 ms could potentially be valuable indicators for monitoring cardiac autonomic nervous dysfunction. |
| format | Article |
| id | doaj-art-17d6e47fd28d446db12094b26c8bacd7 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-17d6e47fd28d446db12094b26c8bacd72025-08-20T02:37:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-12-011110.3389/fcvm.2024.14951291495129Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of ageJijing Wang0Jinyi Xu1Yanyan Qiu2Ruike Yang3Wentao Wang4Chuanyu Gao5Chuanyu Gao6Department of Cardiopulmonary Function, Zhengzhou University People's Hospital (Henan Provincial People's Hospital), Zhengzhou, Henan, ChinaDepartment of Cardiopulmonary Function, Zhengzhou University People's Hospital (Henan Provincial People's Hospital), Zhengzhou, Henan, ChinaDepartment of Cardiopulmonary Function, Zhengzhou University People's Hospital (Henan Provincial People's Hospital), Zhengzhou, Henan, ChinaDepartment of Cardiopulmonary Function, Zhengzhou University People's Hospital (Henan Provincial People's Hospital), Zhengzhou, Henan, ChinaDepartment of Cardiopulmonary Function, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, ChinaDepartment of Cardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, ChinaDepartment of Cardiology, Zhengzhou University People's Hospital (Henan Provincial People's Hospital), Zhengzhou, Henan, ChinaBackgroundDeceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS.MethodsA total of 94 consecutive patients with VVS [51.0 (38.0–60.0) years; 48 males] and 76 healthy subjects [53.0 (44.3–62.8) years; 46 males] were recruited as controls. The study compared DC, AC, and heart rate variability (HRV) in 24-h ECG, echocardiogram, and biochemical examinations between the two groups.ResultsDC was significantly higher (9.3 ± 2.1 vs. 7.4 ± 1.4 ms, p < .001) and AC was lower (−9.3 ± 2.1 vs. −7.3 ± 1.3 ms, p < .001) in the syncope group compared to the control group. HRV indicators were higher in the syncope group. In multivariable analyses, DC [odds ratio = 1.746 (95% CI, 1.389–2.195); p < .001], AC [odds ratio = 0.553 (95% CI, 0.435–0.702); p < .001] were independently associated with syncope. Mean HR was associated with syncope only in patients <60 years of age. Receiver operating characteristics (ROC) curves showed areas under curve (AUC) of DC/AC for predicting syncope are 0.755/0.765 with sensitivity of 56.4%/60.6% and specificity of 93.4%/88.2%.ConclusionPatients with VVS exhibit higher DC and lower AC. Both DC and AC are independently correlated with syncope. A DC value >9.0 ms and an AC value −9.0 ms could potentially be valuable indicators for monitoring cardiac autonomic nervous dysfunction.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1495129/fulldeceleration capacityacceleration capacityvasovagal syncopeautonomic nervous functionsyncope |
| spellingShingle | Jijing Wang Jinyi Xu Yanyan Qiu Ruike Yang Wentao Wang Chuanyu Gao Chuanyu Gao Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age Frontiers in Cardiovascular Medicine deceleration capacity acceleration capacity vasovagal syncope autonomic nervous function syncope |
| title | Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age |
| title_full | Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age |
| title_fullStr | Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age |
| title_full_unstemmed | Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age |
| title_short | Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age |
| title_sort | cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age |
| topic | deceleration capacity acceleration capacity vasovagal syncope autonomic nervous function syncope |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1495129/full |
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