Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma

BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear.MethodsThis study enrolled 32 healthy volunteers and...

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Bibliographic Details
Main Authors:	Mingguang Zhang, Shuohui Dong, Wei Rao, Shiwen Mei, Gang Hu, Ling Liu, Zhen Wang, Jianqiang Tang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	cell-free DNA repetitive element early tumor detection tissue of origin low-pass whole genome sequencing
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1630231/full
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