Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been established as treatment options for patients with peritoneal metastases or peritoneal mesothelioma. However, this novel treatment strategy remains associated with a large percentage of local-regional treatm...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/752643 |
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| author | Paul H. Sugarbaker Lana Bijelic |
| author_facet | Paul H. Sugarbaker Lana Bijelic |
| author_sort | Paul H. Sugarbaker |
| collection | DOAJ |
| description | Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been established as treatment options for patients with peritoneal metastases or peritoneal mesothelioma. However, this novel treatment strategy remains associated with a large percentage of local-regional treatment failures. These treatment failures are attributed to the inadequacy of HIPEC to maintain a surgical complete response. Management strategies to supplement CRS and HIPEC are indicated. A simplified approach to the intraoperative placement of an intraperitoneal port for adjuvant bidirectional chemotherapy (ABC) was devised. Four different chemotherapy treatment plans were utilized depending upon the primary site of the malignancy. Thirty-one consecutive patients with an intraoperative placement of the intraperitoneal port were available for study. The incidence of adverse events that caused an early discontinuation of the bidirectional chemotherapy occurred in 75% of the 8 patients who had an incomplete cytoreduction and in 0% of patients who had a complete cytoreduction. All of the patients who had complete cytoreduction completed at least 5 of the scheduled 6 bidirectional chemotherapy treatments. Adjuvant bidirectional chemotherapy is possible following a major cytoreductive surgical procedure using a simplified method of intraoperative intraperitoneal port placement. |
| format | Article |
| id | doaj-art-17c15246529d4bc786c3b574ea77a5ef |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-17c15246529d4bc786c3b574ea77a5ef2025-08-20T03:54:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/752643752643Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal PortPaul H. Sugarbaker0Lana Bijelic1Program in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington, DC 20010, USAProgram in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington, DC 20010, USACytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been established as treatment options for patients with peritoneal metastases or peritoneal mesothelioma. However, this novel treatment strategy remains associated with a large percentage of local-regional treatment failures. These treatment failures are attributed to the inadequacy of HIPEC to maintain a surgical complete response. Management strategies to supplement CRS and HIPEC are indicated. A simplified approach to the intraoperative placement of an intraperitoneal port for adjuvant bidirectional chemotherapy (ABC) was devised. Four different chemotherapy treatment plans were utilized depending upon the primary site of the malignancy. Thirty-one consecutive patients with an intraoperative placement of the intraperitoneal port were available for study. The incidence of adverse events that caused an early discontinuation of the bidirectional chemotherapy occurred in 75% of the 8 patients who had an incomplete cytoreduction and in 0% of patients who had a complete cytoreduction. All of the patients who had complete cytoreduction completed at least 5 of the scheduled 6 bidirectional chemotherapy treatments. Adjuvant bidirectional chemotherapy is possible following a major cytoreductive surgical procedure using a simplified method of intraoperative intraperitoneal port placement.http://dx.doi.org/10.1155/2012/752643 |
| spellingShingle | Paul H. Sugarbaker Lana Bijelic Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port Gastroenterology Research and Practice |
| title | Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port |
| title_full | Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port |
| title_fullStr | Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port |
| title_full_unstemmed | Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port |
| title_short | Adjuvant Bidirectional Chemotherapy Using an Intraperitoneal Port |
| title_sort | adjuvant bidirectional chemotherapy using an intraperitoneal port |
| url | http://dx.doi.org/10.1155/2012/752643 |
| work_keys_str_mv | AT paulhsugarbaker adjuvantbidirectionalchemotherapyusinganintraperitonealport AT lanabijelic adjuvantbidirectionalchemotherapyusinganintraperitonealport |