An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters
Abstract Background Characterizing malaria burden and its evolution is complicated by the high levels of spatio-temporal heterogeneity and by the complexity of the transmission process. Main body This manuscript presents an integrative review of the combined use of mathematical and statistical model...
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BMC
2025-05-01
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| Series: | Malaria Journal |
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| Online Access: | https://doi.org/10.1186/s12936-025-05415-5 |
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| author | Alessandro Grosso Niel Hens Steven Abrams |
| author_facet | Alessandro Grosso Niel Hens Steven Abrams |
| author_sort | Alessandro Grosso |
| collection | DOAJ |
| description | Abstract Background Characterizing malaria burden and its evolution is complicated by the high levels of spatio-temporal heterogeneity and by the complexity of the transmission process. Main body This manuscript presents an integrative review of the combined use of mathematical and statistical models to estimate malaria transmission parameters. Therefore, this work aims to provide a solid methodological foundation for the estimation of transmission intensity and other relevant quantities. A perspective covering both mathematical and statistical models to appraise commonly used metrics is adopted and subsequently their inclusion as parameters in compartmental models as well as their estimation from available data is discussed. The current review argues in favour of a more widespread consideration of the Force of Infection (FOI) as a malaria transmission metric. Using the FOI dispenses the analyst from explicitly describing vector dynamics in compartmental modelling, simplifying the system of differential equations describing transmission dynamics. In turn, its estimation can be flexibly performed by solely relying on host data, such as parasitaemia or serology, avoiding the need for entomological data. Conclusion The present work argues that the interaction between mathematical and statistical models, although previously exemplified by others, is underappreciated when modelling malaria transmission. Orienting the exposition around the FOI provides an illustration of the potential borne by the existing methodology. A connection between the two modelling frameworks warrants better scrutiny, as it leads to the possibility of exploiting the full range of modern statistical methods. |
| format | Article |
| id | doaj-art-17c047e9d92b43b39c424e5da94de699 |
| institution | OA Journals |
| issn | 1475-2875 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj-art-17c047e9d92b43b39c424e5da94de6992025-08-20T02:00:00ZengBMCMalaria Journal1475-28752025-05-0124111810.1186/s12936-025-05415-5An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parametersAlessandro Grosso0Niel Hens1Steven Abrams2Global Health Institute, Department of Family Medicine and Population Health, University of AntwerpData Science Institute, Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt UniversityGlobal Health Institute, Department of Family Medicine and Population Health, University of AntwerpAbstract Background Characterizing malaria burden and its evolution is complicated by the high levels of spatio-temporal heterogeneity and by the complexity of the transmission process. Main body This manuscript presents an integrative review of the combined use of mathematical and statistical models to estimate malaria transmission parameters. Therefore, this work aims to provide a solid methodological foundation for the estimation of transmission intensity and other relevant quantities. A perspective covering both mathematical and statistical models to appraise commonly used metrics is adopted and subsequently their inclusion as parameters in compartmental models as well as their estimation from available data is discussed. The current review argues in favour of a more widespread consideration of the Force of Infection (FOI) as a malaria transmission metric. Using the FOI dispenses the analyst from explicitly describing vector dynamics in compartmental modelling, simplifying the system of differential equations describing transmission dynamics. In turn, its estimation can be flexibly performed by solely relying on host data, such as parasitaemia or serology, avoiding the need for entomological data. Conclusion The present work argues that the interaction between mathematical and statistical models, although previously exemplified by others, is underappreciated when modelling malaria transmission. Orienting the exposition around the FOI provides an illustration of the potential borne by the existing methodology. A connection between the two modelling frameworks warrants better scrutiny, as it leads to the possibility of exploiting the full range of modern statistical methods.https://doi.org/10.1186/s12936-025-05415-5Malaria transmissionMathematical modelsStatistical modelsForce of infection |
| spellingShingle | Alessandro Grosso Niel Hens Steven Abrams An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters Malaria Journal Malaria transmission Mathematical models Statistical models Force of infection |
| title | An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters |
| title_full | An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters |
| title_fullStr | An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters |
| title_full_unstemmed | An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters |
| title_short | An integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters |
| title_sort | integrative review of the combined use of mathematical and statistical models for estimating malaria transmission parameters |
| topic | Malaria transmission Mathematical models Statistical models Force of infection |
| url | https://doi.org/10.1186/s12936-025-05415-5 |
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