Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment
Muscle-specific tyrosine kinase- (MuSK-) antibodies-positive Myasthenia Gravis accounts for about one third of Seronegative Myasthenia Gravis and is clinically characterized by early onset of prominent bulbar, neck, shoulder girdle, and respiratory weakness. The response to medical therapy is genera...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/859802 |
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| author | S. Lanfranconi S. Corti P. Baron G. Conti L. Borellini N. Bresolin A. Bersano |
| author_facet | S. Lanfranconi S. Corti P. Baron G. Conti L. Borellini N. Bresolin A. Bersano |
| author_sort | S. Lanfranconi |
| collection | DOAJ |
| description | Muscle-specific tyrosine kinase- (MuSK-) antibodies-positive Myasthenia Gravis accounts for about one third of Seronegative Myasthenia Gravis and is clinically characterized by early onset of prominent bulbar, neck, shoulder girdle, and respiratory weakness. The response to medical therapy is generally poor. Here we report a case of late-onset MuSK-antibodies-positive Myasthenia Gravis presenting with signs of cognitive impairment and parkinsonism in addition to bulbar involvement and external ophthalmoplegia. The pattern of involvement of both peripheral and central nervous system dysfunction might suggest a common pathogenic mechanism, involving impaired cholinergic transmission. |
| format | Article |
| id | doaj-art-17b72866934d4f02b46c45fe5fa29341 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-17b72866934d4f02b46c45fe5fa293412025-02-03T05:45:08ZengWileyNeurology Research International2090-18522090-18602011-01-01201110.1155/2011/859802859802Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive ImpairmentS. Lanfranconi0S. Corti1P. Baron2G. Conti3L. Borellini4N. Bresolin5A. Bersano6Department of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyDepartment of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyDepartment of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyDepartment of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyDepartment of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyDepartment of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyDepartment of Neurological Sciences, Dino Ferrari Centre, University of Milan, 20122 Milan, ItalyMuscle-specific tyrosine kinase- (MuSK-) antibodies-positive Myasthenia Gravis accounts for about one third of Seronegative Myasthenia Gravis and is clinically characterized by early onset of prominent bulbar, neck, shoulder girdle, and respiratory weakness. The response to medical therapy is generally poor. Here we report a case of late-onset MuSK-antibodies-positive Myasthenia Gravis presenting with signs of cognitive impairment and parkinsonism in addition to bulbar involvement and external ophthalmoplegia. The pattern of involvement of both peripheral and central nervous system dysfunction might suggest a common pathogenic mechanism, involving impaired cholinergic transmission.http://dx.doi.org/10.1155/2011/859802 |
| spellingShingle | S. Lanfranconi S. Corti P. Baron G. Conti L. Borellini N. Bresolin A. Bersano Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment Neurology Research International |
| title | Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment |
| title_full | Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment |
| title_fullStr | Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment |
| title_full_unstemmed | Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment |
| title_short | Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment |
| title_sort | anti musk positive myasthenia gravis in a patient with parkinsonism and cognitive impairment |
| url | http://dx.doi.org/10.1155/2011/859802 |
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