Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study
BackgroundUNISCREEN is a general population study aiming at evaluating feasibility and acceptability of universal screening for chronic autoimmune (type 1 diabetes and celiac disease) and metabolic/cardiovascular diseases (dysglycemia, type 2 diabetes, dyslipidemia, hypertension) across all age grou...
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Frontiers Media S.A.
2025-02-01
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| author | Sara Angiulli Aurora Merolla Elisa Borgonovo Rebecca De Lorenzo Serena Spadoni Barbara Fontana Giuseppina Manganaro Elena Rela Alberto Bongiovanni Rita Peracino Chiara Bellino Giulia Pata Eleonora Bianconi Sabina Martinenghi Francesca Ulivi Cristina Renzi Cristina Renzi Emanuele Bosi Emanuele Bosi UNISCREEN Study Group Sara Angiulli Aurora Merolla Alberto Bongiovanni Rebecca De Lorenzo Elena Rela Rita Peracino Chiara Bellino Giuseppina Manganaro Elisa Borgonovo Sara Critelli Aldo Fici Martina Mallus Giulia Morocutti Giulia Pata Clara Soggetti Chiara Calabrese Alberico Di Resta Maria Pia Ruggiero Antonella Spano’ Francesca Biasco Manuel Stocchi Pietro Melodia Giuseppe Ancona Andrea Laurenzi |
| author_facet | Sara Angiulli Aurora Merolla Elisa Borgonovo Rebecca De Lorenzo Serena Spadoni Barbara Fontana Giuseppina Manganaro Elena Rela Alberto Bongiovanni Rita Peracino Chiara Bellino Giulia Pata Eleonora Bianconi Sabina Martinenghi Francesca Ulivi Cristina Renzi Cristina Renzi Emanuele Bosi Emanuele Bosi UNISCREEN Study Group Sara Angiulli Aurora Merolla Alberto Bongiovanni Rebecca De Lorenzo Elena Rela Rita Peracino Chiara Bellino Giuseppina Manganaro Elisa Borgonovo Sara Critelli Aldo Fici Martina Mallus Giulia Morocutti Giulia Pata Clara Soggetti Chiara Calabrese Alberico Di Resta Maria Pia Ruggiero Antonella Spano’ Francesca Biasco Manuel Stocchi Pietro Melodia Giuseppe Ancona Andrea Laurenzi |
| author_sort | Sara Angiulli |
| collection | DOAJ |
| description | BackgroundUNISCREEN is a general population study aiming at evaluating feasibility and acceptability of universal screening for chronic autoimmune (type 1 diabetes and celiac disease) and metabolic/cardiovascular diseases (dysglycemia, type 2 diabetes, dyslipidemia, hypertension) across all age groups using capillary blood sampling by fingerprick to measure disease risk markers.MethodsUNISCREEN was conducted in the Cantalupo fraction, Cerro Maggiore, Milan, Italy, counting 3,061 inhabitants between 1 and 100 years of age. Participation was voluntary, following a public call. Participants were invited to respond to feasibility and acceptability questionnaires immediately before and after the screening procedures, which included the following: capillary blood drawing for immediate measurement of metabolic parameters (glucose, glycated hemoglobin, total-, HDL- and calculated LDL-cholesterol, triglycerides) and late autoantibody assays; blood pressure measurement; brief consultation with a physician providing feed-back on immediate results and health recommendations. The study was registered as ClinicalTrials.gov NCT05841719.ResultsThe study included 1,535 participants (50.1% of local population). A single fingerprick was sufficient for all measurements in 47.1% of cases, while up to two were necessary in 86.9% of cases. Complete glucose and lipid panels were obtained in 1382 participants (90.0%). Sufficient serum for late autoantibody testing was obtained in 99.7% of participants. The questionnaires showed overall satisfaction, with over 90% of participants considering capillary sampling simple and practical, and preferring it to venous sampling. Before screening, 24.0% adults and 31.7% children’s parents were worried about the possibility of being diagnosed or identified as being at risk; worries decreased to 21.3 and 23.4%, respectively, after medical consultation. The immediacy of some result communication possibly contributed to reducing the anticipatory anxiety.ConclusionThe UNISCREEN study shows that universal screening for chronic autoimmune, metabolic and cardiovascular diseases in the general population using capillary blood testing is feasible and acceptable. |
| format | Article |
| id | doaj-art-17b547994a7640a9a0996214606384b7 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-17b547994a7640a9a0996214606384b72025-02-11T06:59:17ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-02-011310.3389/fpubh.2025.15062401506240Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN studySara Angiulli0Aurora Merolla1Elisa Borgonovo2Rebecca De Lorenzo3Serena Spadoni4Barbara Fontana5Giuseppina Manganaro6Elena Rela7Alberto Bongiovanni8Rita Peracino9Chiara Bellino10Giulia Pata11Eleonora Bianconi12Sabina Martinenghi13Francesca Ulivi14Cristina Renzi15Cristina Renzi16Emanuele Bosi17Emanuele Bosi18UNISCREEN Study GroupSara AngiulliAurora MerollaAlberto BongiovanniRebecca De LorenzoElena RelaRita PeracinoChiara BellinoGiuseppina ManganaroElisa BorgonovoSara CritelliAldo FiciMartina MallusGiulia MorocuttiGiulia PataClara SoggettiChiara CalabreseAlberico Di RestaMaria Pia RuggieroAntonella Spano’Francesca BiascoManuel StocchiPietro MelodiaGiuseppe AnconaAndrea LaurenziVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyFondazione Italiana Diabete (FID), Milan, ItalyVita-Salute San Raffaele University, Milan, ItalyBehavioural Science and Health, Institute of Epidemiology & Health Care, University College London, London, United KingdomVita-Salute San Raffaele University, Milan, ItalyDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, ItalyBackgroundUNISCREEN is a general population study aiming at evaluating feasibility and acceptability of universal screening for chronic autoimmune (type 1 diabetes and celiac disease) and metabolic/cardiovascular diseases (dysglycemia, type 2 diabetes, dyslipidemia, hypertension) across all age groups using capillary blood sampling by fingerprick to measure disease risk markers.MethodsUNISCREEN was conducted in the Cantalupo fraction, Cerro Maggiore, Milan, Italy, counting 3,061 inhabitants between 1 and 100 years of age. Participation was voluntary, following a public call. Participants were invited to respond to feasibility and acceptability questionnaires immediately before and after the screening procedures, which included the following: capillary blood drawing for immediate measurement of metabolic parameters (glucose, glycated hemoglobin, total-, HDL- and calculated LDL-cholesterol, triglycerides) and late autoantibody assays; blood pressure measurement; brief consultation with a physician providing feed-back on immediate results and health recommendations. The study was registered as ClinicalTrials.gov NCT05841719.ResultsThe study included 1,535 participants (50.1% of local population). A single fingerprick was sufficient for all measurements in 47.1% of cases, while up to two were necessary in 86.9% of cases. Complete glucose and lipid panels were obtained in 1382 participants (90.0%). Sufficient serum for late autoantibody testing was obtained in 99.7% of participants. The questionnaires showed overall satisfaction, with over 90% of participants considering capillary sampling simple and practical, and preferring it to venous sampling. Before screening, 24.0% adults and 31.7% children’s parents were worried about the possibility of being diagnosed or identified as being at risk; worries decreased to 21.3 and 23.4%, respectively, after medical consultation. The immediacy of some result communication possibly contributed to reducing the anticipatory anxiety.ConclusionThe UNISCREEN study shows that universal screening for chronic autoimmune, metabolic and cardiovascular diseases in the general population using capillary blood testing is feasible and acceptable.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1506240/fullfeasibility and acceptabilitypopulation screeningcapillary bloodtype 1 diabetesceliac diseasetype 2 diabetes |
| spellingShingle | Sara Angiulli Aurora Merolla Elisa Borgonovo Rebecca De Lorenzo Serena Spadoni Barbara Fontana Giuseppina Manganaro Elena Rela Alberto Bongiovanni Rita Peracino Chiara Bellino Giulia Pata Eleonora Bianconi Sabina Martinenghi Francesca Ulivi Cristina Renzi Cristina Renzi Emanuele Bosi Emanuele Bosi UNISCREEN Study Group Sara Angiulli Aurora Merolla Alberto Bongiovanni Rebecca De Lorenzo Elena Rela Rita Peracino Chiara Bellino Giuseppina Manganaro Elisa Borgonovo Sara Critelli Aldo Fici Martina Mallus Giulia Morocutti Giulia Pata Clara Soggetti Chiara Calabrese Alberico Di Resta Maria Pia Ruggiero Antonella Spano’ Francesca Biasco Manuel Stocchi Pietro Melodia Giuseppe Ancona Andrea Laurenzi Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study Frontiers in Public Health feasibility and acceptability population screening capillary blood type 1 diabetes celiac disease type 2 diabetes |
| title | Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study |
| title_full | Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study |
| title_fullStr | Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study |
| title_full_unstemmed | Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study |
| title_short | Universal capillary screening for chronic autoimmune, metabolic and cardiovascular diseases: feasibility and acceptability of the UNISCREEN study |
| title_sort | universal capillary screening for chronic autoimmune metabolic and cardiovascular diseases feasibility and acceptability of the uniscreen study |
| topic | feasibility and acceptability population screening capillary blood type 1 diabetes celiac disease type 2 diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1506240/full |
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