Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies

Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies

T cell bispecific antibodies (TCBs) have demonstrated promising results in patients with solid tumors, yet the immunological mechanisms influencing their efficacy require further investigation. T cell exhaustion, induced by prolonged antigen exposure, is known to compromise T cell-based immunotherap...

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Bibliographic Details
Main Authors: Idil Hutter-Karakoc, Eleni Maria Varypataki, Aparna Neelakandhan, Simone Lang, Vesna Kramar, Ahmet Varol, Sasha Simons, Marine Richard, Mudita Pincha, Dario Venetz, Johannes Sam, Nicole Joller, Christian Münz, Pablo Umana, Christian Klein, Maria Amann
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Cancer immunotherapy
T cell engagers
T cell bispecific antibodies
T cell exhaustion
chronic antigen stimulation
antigen-specific T cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2526444
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