The poly (ADP-ribose) polymerase inhibitor olaparib attenuates established pulmonary fibrosis in a large animal model

The poly (ADP-ribose) polymerase inhibitor olaparib attenuates established pulmonary fibrosis in a large animal model

Abstract Background Poly (ADP‒ribose) polymerase (PARP) is a constitutive enzyme involved in regulating various biological processes in health and disease. In the present study, we investigated the role of PARP1 in pulmonary fibrosis and assessed the efficacy of a clinically approved PARP inhibitor,...

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Bibliographic Details
Main Authors: Habtamu B. Derseh, Andrew N. Davies, Alarna Young, Sylvie Bischof, Joseph Pelle, David Rudd, Michelle McIntosh, David Piedrafita, Robert J. Bischof
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Pulmonary Medicine
Subjects:
Bleomycin
Fibrosis
Large animal model
Olaparib
PARP
Repurposing
Online Access:https://doi.org/10.1186/s12890-025-03803-w
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