Circular RNAs: novel noncoding players in male infertility
Abstract Infertility is a global problem being associated with emotional and financial burden. Recent studies have shown contribution of a group of non-coding RNAs, namely circular RNAs (circRNAs) to the etiology of some infertility conditions. CircRNA are transcribed from exons and form a circular...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Hereditas |
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| Online Access: | https://doi.org/10.1186/s41065-024-00346-8 |
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| author | Emad Babakhanzadeh Fakhr-Alsadat Hoseininasab Ali Khodadadian Majid Nazari Reza Hajati Soudeh Ghafouri-Fard |
| author_facet | Emad Babakhanzadeh Fakhr-Alsadat Hoseininasab Ali Khodadadian Majid Nazari Reza Hajati Soudeh Ghafouri-Fard |
| author_sort | Emad Babakhanzadeh |
| collection | DOAJ |
| description | Abstract Infertility is a global problem being associated with emotional and financial burden. Recent studies have shown contribution of a group of non-coding RNAs, namely circular RNAs (circRNAs) to the etiology of some infertility conditions. CircRNA are transcribed from exons and form a circular RNA molecule, being abundant in eukaryotes. Traditionally classified as non-coding RNA, these transcripts are endogenously produced through either non-canonical back-splicing or linear splicing, typically produced from precursor messenger ribonucleic acid (pre-mRNA). While during the canonical splicing process the 3’ end of the exon is joined to the 5’ end of the succeeding exon to form linear mRNA, during backsplicing, the 3’ end to the 5’ end of the same exon is joined to make a circular molecule. circRNAs are involved in the regulation of several aspects of spermatogenesis. They appear to influence how stem germ cells grow and divide during the sperm production process. Malfunctions in circRNA activity could contribute to male infertility issues stemming from abnormalities in spermatogenesis. In the current review, we highlight the exciting potential of circRNAs as key players in the male fertility. |
| format | Article |
| id | doaj-art-17a9c26fbab4434d8fded77cc232b77e |
| institution | Kabale University |
| issn | 1601-5223 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditas |
| spelling | doaj-art-17a9c26fbab4434d8fded77cc232b77e2024-11-24T12:28:50ZengBMCHereditas1601-52232024-11-01161111410.1186/s41065-024-00346-8Circular RNAs: novel noncoding players in male infertilityEmad Babakhanzadeh0Fakhr-Alsadat Hoseininasab1Ali Khodadadian2Majid Nazari3Reza Hajati4Soudeh Ghafouri-Fard5Department of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Immunology, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Sadoughi University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesAbstract Infertility is a global problem being associated with emotional and financial burden. Recent studies have shown contribution of a group of non-coding RNAs, namely circular RNAs (circRNAs) to the etiology of some infertility conditions. CircRNA are transcribed from exons and form a circular RNA molecule, being abundant in eukaryotes. Traditionally classified as non-coding RNA, these transcripts are endogenously produced through either non-canonical back-splicing or linear splicing, typically produced from precursor messenger ribonucleic acid (pre-mRNA). While during the canonical splicing process the 3’ end of the exon is joined to the 5’ end of the succeeding exon to form linear mRNA, during backsplicing, the 3’ end to the 5’ end of the same exon is joined to make a circular molecule. circRNAs are involved in the regulation of several aspects of spermatogenesis. They appear to influence how stem germ cells grow and divide during the sperm production process. Malfunctions in circRNA activity could contribute to male infertility issues stemming from abnormalities in spermatogenesis. In the current review, we highlight the exciting potential of circRNAs as key players in the male fertility.https://doi.org/10.1186/s41065-024-00346-8Non-coding RNAscircRNAMale infertilitySpermatogenesis |
| spellingShingle | Emad Babakhanzadeh Fakhr-Alsadat Hoseininasab Ali Khodadadian Majid Nazari Reza Hajati Soudeh Ghafouri-Fard Circular RNAs: novel noncoding players in male infertility Hereditas Non-coding RNAs circRNA Male infertility Spermatogenesis |
| title | Circular RNAs: novel noncoding players in male infertility |
| title_full | Circular RNAs: novel noncoding players in male infertility |
| title_fullStr | Circular RNAs: novel noncoding players in male infertility |
| title_full_unstemmed | Circular RNAs: novel noncoding players in male infertility |
| title_short | Circular RNAs: novel noncoding players in male infertility |
| title_sort | circular rnas novel noncoding players in male infertility |
| topic | Non-coding RNAs circRNA Male infertility Spermatogenesis |
| url | https://doi.org/10.1186/s41065-024-00346-8 |
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