Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood
Abstract Limb-salvage after (sub-) total humerus resection in skeletally immature patients, aged less than 10 years, remains the domain of individual case decisions due to a small number of affected patients. Seven children aged ≤ 10 years at the time of (sub-) total bone sarcoma resection of the hu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-025-05956-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849705224201043968 |
|---|---|
| author | Wiebke K. Guder Nina M. Engel Jendrik Hardes Lars E. Podleska Dimosthenis Andreou Markus Nottrott Arne Streitbürger |
| author_facet | Wiebke K. Guder Nina M. Engel Jendrik Hardes Lars E. Podleska Dimosthenis Andreou Markus Nottrott Arne Streitbürger |
| author_sort | Wiebke K. Guder |
| collection | DOAJ |
| description | Abstract Limb-salvage after (sub-) total humerus resection in skeletally immature patients, aged less than 10 years, remains the domain of individual case decisions due to a small number of affected patients. Seven children aged ≤ 10 years at the time of (sub-) total bone sarcoma resection of the humerus between 2018 and 2023 were included in this retrospective study. Limb salvage with an intact motor function of the lower arm was achieved in 100% of cases at a mean follow-up of 89.8 months. Reconstruction survival was 28.6%. 61.8% (n = 8/13) of complications necessitated revision operations (n = 7). Distal instability and dislocation (n = 5) was the most frequently observed complication, followed by periprosthetic infection (n = 2). However, both fixed hinge prostheses and hemiprostheses with a highly cancellous implant body led to stable reconstructions of the elbow joint. Arm lengthening (5 cm) was successful in two patients who underwent implantation of a growing prosthesis. Patients developed a handedness contralateral to the operated arm in this study. The mean MSTS and TESS scores were 16.6 and 51.5. Patients suffered from a limited range of motion in the glenohumeral joint, limited fine motor function and strength despite an intact innervation of the executing muscles. Salvage of even short segments of the distal humerus has a high potential to decrease complication rates, whenever oncologically feasible. The use of fixed-hinge total humerus (growing) prostheses and custom-made total humerus hemiprostheses with a highly cancellous implant body showed the most promising results in terms of complications and functional outcomes. Arm lengthening using growing prostheses - albeit of a mostly cosmetic value - is an option in the upper extremity whenever the soft tissue coverage of the implant is adequate. |
| format | Article |
| id | doaj-art-17a8fe728e434fdfbfe1e8e61e2c57b1 |
| institution | DOAJ |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-17a8fe728e434fdfbfe1e8e61e2c57b12025-08-20T03:16:32ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-05-0120111210.1186/s13018-025-05956-0Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhoodWiebke K. Guder0Nina M. Engel1Jendrik Hardes2Lars E. Podleska3Dimosthenis Andreou4Markus Nottrott5Arne Streitbürger6Department of Orthopedic Oncology, University Hospital EssenDepartment of Orthopedic Oncology, University Hospital EssenDepartment of Orthopedic Oncology, University Hospital EssenDepartment of Orthopedic Oncology, University Hospital EssenDepartment of Orthopedic Oncology, University Hospital EssenDepartment of Orthopedic Oncology, University Hospital EssenDepartment of Orthopedic Oncology, University Hospital EssenAbstract Limb-salvage after (sub-) total humerus resection in skeletally immature patients, aged less than 10 years, remains the domain of individual case decisions due to a small number of affected patients. Seven children aged ≤ 10 years at the time of (sub-) total bone sarcoma resection of the humerus between 2018 and 2023 were included in this retrospective study. Limb salvage with an intact motor function of the lower arm was achieved in 100% of cases at a mean follow-up of 89.8 months. Reconstruction survival was 28.6%. 61.8% (n = 8/13) of complications necessitated revision operations (n = 7). Distal instability and dislocation (n = 5) was the most frequently observed complication, followed by periprosthetic infection (n = 2). However, both fixed hinge prostheses and hemiprostheses with a highly cancellous implant body led to stable reconstructions of the elbow joint. Arm lengthening (5 cm) was successful in two patients who underwent implantation of a growing prosthesis. Patients developed a handedness contralateral to the operated arm in this study. The mean MSTS and TESS scores were 16.6 and 51.5. Patients suffered from a limited range of motion in the glenohumeral joint, limited fine motor function and strength despite an intact innervation of the executing muscles. Salvage of even short segments of the distal humerus has a high potential to decrease complication rates, whenever oncologically feasible. The use of fixed-hinge total humerus (growing) prostheses and custom-made total humerus hemiprostheses with a highly cancellous implant body showed the most promising results in terms of complications and functional outcomes. Arm lengthening using growing prostheses - albeit of a mostly cosmetic value - is an option in the upper extremity whenever the soft tissue coverage of the implant is adequate.https://doi.org/10.1186/s13018-025-05956-0ChildhoodComplication managementEwing sarcomaLimb salvageOsteosarcomaPrimary bone tumor |
| spellingShingle | Wiebke K. Guder Nina M. Engel Jendrik Hardes Lars E. Podleska Dimosthenis Andreou Markus Nottrott Arne Streitbürger Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood Journal of Orthopaedic Surgery and Research Childhood Complication management Ewing sarcoma Limb salvage Osteosarcoma Primary bone tumor |
| title | Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood |
| title_full | Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood |
| title_fullStr | Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood |
| title_full_unstemmed | Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood |
| title_short | Limb salvage and complication management after (sub-) total humerus resection for primary malignant bone tumors in early childhood |
| title_sort | limb salvage and complication management after sub total humerus resection for primary malignant bone tumors in early childhood |
| topic | Childhood Complication management Ewing sarcoma Limb salvage Osteosarcoma Primary bone tumor |
| url | https://doi.org/10.1186/s13018-025-05956-0 |
| work_keys_str_mv | AT wiebkekguder limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood AT ninamengel limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood AT jendrikhardes limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood AT larsepodleska limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood AT dimosthenisandreou limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood AT markusnottrott limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood AT arnestreitburger limbsalvageandcomplicationmanagementaftersubtotalhumerusresectionforprimarymalignantbonetumorsinearlychildhood |