The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial
Abstract Background Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. Method This clinical trial study was conducted on 141 pediatric ALL patients, all ove...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-025-13751-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849332868311941120 |
|---|---|
| author | Aziz Eghbali Mahsa Adibifar Ali Ghasemi Roghayeh Rahimi Afzal Katayoun Moradi Aygin Eghbali Foroozan Faress Kazem Ghaffari |
| author_facet | Aziz Eghbali Mahsa Adibifar Ali Ghasemi Roghayeh Rahimi Afzal Katayoun Moradi Aygin Eghbali Foroozan Faress Kazem Ghaffari |
| author_sort | Aziz Eghbali |
| collection | DOAJ |
| description | Abstract Background Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. Method This clinical trial study was conducted on 141 pediatric ALL patients, all over 5 years old. The subjects were randomly divided into a curcumin-treatment group and a placebo group. In the curcumin-treatment group, patients received 3 mg/kg oral curcumin capsules twice a day for 3 months. In the placebo cohort, participants were administered placebo capsules twice a day for 3 months. Administration of VCR was started in all patients in both groups, with a weekly dose of 1.5 mg/m2. Result Overall, 39.4% of participants in the curcumin treatment group and 70.0% in the placebo group had VIPN. Thus, a significant difference in the incidence of VIPN was observed in the two groups (P < 0.001). A significantly higher frequency of motor nerve abnormalities in all types of nerves was observed in the placebo group than in the curcumin treatment group (P < 0.05). Conclusions The results of our study showed that curcumin is effective in preventing the development of VIPN and leads to the improvement of VIPN in these patients. Our findings indicate that the prevalence of VIPN was substantially lower in the curcumin-treated group compared to the placebo group, as confirmed by both NCS and EMG assessments. Furthermore, curcumin demonstrated a protective effect against motor and sensory nerve damage, with a significant reduction in motor nerve abnormalities. Trial registration This study was registered at https://irct.behdasht.gov.ir/trial/73161 . Trial registration number: IRCT20201107049296N3. Date of registration: 2022-09-11. |
| format | Article |
| id | doaj-art-17a828fda2814329b050cdacb1939d91 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-17a828fda2814329b050cdacb1939d912025-08-20T03:46:04ZengBMCBMC Cancer1471-24072025-02-012511910.1186/s12885-025-13751-7The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trialAziz Eghbali0Mahsa Adibifar1Ali Ghasemi2Roghayeh Rahimi Afzal3Katayoun Moradi4Aygin Eghbali5Foroozan Faress6Kazem Ghaffari7Clinical Research Development Center of Aliasghar Hospital, Iran University of Medical SciencesClinical Research Development Center of Aliasghar Hospital, Iran University of Medical SciencesCancer Research Center, Semnan University of Medical SciencesDepartment of Pediatrics, Amir Kabir Hospital, Arak University of Medical SciencesNeuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical SciencesSchool of Medicine, Iran University of Medical SciencesDepartment of Forensic Medicine and Toxicology, School of Medicine, Iran University of Medical SciencesDepartment of Hematology and Blood Transfusion Sciences, School of Allied Medical Sciences, Tehran University of Medical SciencesAbstract Background Peripheral neuropathy is a major adverse effect of Vincristine (VCR) in pediatric acute lymphoblastic leukemia (ALL) patients. Curcumin can prevent the development of many neurological diseases. Method This clinical trial study was conducted on 141 pediatric ALL patients, all over 5 years old. The subjects were randomly divided into a curcumin-treatment group and a placebo group. In the curcumin-treatment group, patients received 3 mg/kg oral curcumin capsules twice a day for 3 months. In the placebo cohort, participants were administered placebo capsules twice a day for 3 months. Administration of VCR was started in all patients in both groups, with a weekly dose of 1.5 mg/m2. Result Overall, 39.4% of participants in the curcumin treatment group and 70.0% in the placebo group had VIPN. Thus, a significant difference in the incidence of VIPN was observed in the two groups (P < 0.001). A significantly higher frequency of motor nerve abnormalities in all types of nerves was observed in the placebo group than in the curcumin treatment group (P < 0.05). Conclusions The results of our study showed that curcumin is effective in preventing the development of VIPN and leads to the improvement of VIPN in these patients. Our findings indicate that the prevalence of VIPN was substantially lower in the curcumin-treated group compared to the placebo group, as confirmed by both NCS and EMG assessments. Furthermore, curcumin demonstrated a protective effect against motor and sensory nerve damage, with a significant reduction in motor nerve abnormalities. Trial registration This study was registered at https://irct.behdasht.gov.ir/trial/73161 . Trial registration number: IRCT20201107049296N3. Date of registration: 2022-09-11.https://doi.org/10.1186/s12885-025-13751-7CurcuminAcute lymphoblastic leukemiaPediatricsVincristineNeuropathy |
| spellingShingle | Aziz Eghbali Mahsa Adibifar Ali Ghasemi Roghayeh Rahimi Afzal Katayoun Moradi Aygin Eghbali Foroozan Faress Kazem Ghaffari The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial BMC Cancer Curcumin Acute lymphoblastic leukemia Pediatrics Vincristine Neuropathy |
| title | The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial |
| title_full | The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial |
| title_fullStr | The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial |
| title_full_unstemmed | The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial |
| title_short | The effect of oral curcumin on vincristine-induced neuropathy in pediatric acute lymphoblastic leukemia: A double-blind randomized controlled clinical trial |
| title_sort | effect of oral curcumin on vincristine induced neuropathy in pediatric acute lymphoblastic leukemia a double blind randomized controlled clinical trial |
| topic | Curcumin Acute lymphoblastic leukemia Pediatrics Vincristine Neuropathy |
| url | https://doi.org/10.1186/s12885-025-13751-7 |
| work_keys_str_mv | AT azizeghbali theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT mahsaadibifar theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT alighasemi theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT roghayehrahimiafzal theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT katayounmoradi theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT aygineghbali theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT foroozanfaress theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT kazemghaffari theeffectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT azizeghbali effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT mahsaadibifar effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT alighasemi effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT roghayehrahimiafzal effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT katayounmoradi effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT aygineghbali effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT foroozanfaress effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial AT kazemghaffari effectoforalcurcuminonvincristineinducedneuropathyinpediatricacutelymphoblasticleukemiaadoubleblindrandomizedcontrolledclinicaltrial |