Usual walking Pace and risk of 28 cancers– results from the UK biobank
Abstract Background Usual walking pace represents a practical indicator of overall health. However, its association with cancer development remains unexplored. We investigated the relation between self-reported walking pace and cancer risk. Methods Using baseline UK Biobank data from 2006 to 2010, e...
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BMC
2025-05-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-14258-x |
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| author | Michael J. Stein Hansjörg Baurecht Patricia Bohmann Pietro Ferrari Béatrice Fervers Emma Fontvieille Heinz Freisling Christine M. Friedenreich Marc J. Gunter Laia Peruchet-Noray Anja M. Sedlmeier Andrea Weber Michael F. Leitzmann Julian Konzok |
| author_facet | Michael J. Stein Hansjörg Baurecht Patricia Bohmann Pietro Ferrari Béatrice Fervers Emma Fontvieille Heinz Freisling Christine M. Friedenreich Marc J. Gunter Laia Peruchet-Noray Anja M. Sedlmeier Andrea Weber Michael F. Leitzmann Julian Konzok |
| author_sort | Michael J. Stein |
| collection | DOAJ |
| description | Abstract Background Usual walking pace represents a practical indicator of overall health. However, its association with cancer development remains unexplored. We investigated the relation between self-reported walking pace and cancer risk. Methods Using baseline UK Biobank data from 2006 to 2010, excluding the first two years of follow-up to reduce reverse causation, we employed multivariable Cox regression to assess the association between walking pace (slow, steady average, brisk) and risk of 28 cancer types, accounting for overall physical activity and walking volume. Results After a median follow-up of 10.9 years (interquartile range 10.1–11.8), 8.3% of 334,924 participants received a cancer diagnosis. Brisk compared to slow walking pace was associated with multivariable-adjusted lower risks of five cancers, including anal (hazard ratio 0.30; 95% confidence interval: 0.14–0.63), hepatocellular carcinoma (0.39; 0.23–0.66), small intestine (0.46; 0.24–0.87), thyroid (0.50; 0.29–0.86), and lung cancer (0.60; 0.51–0.70). Our findings were consistent across various sensitivity analyses, which assessed sex and age differences, residual confounding, and reverse causation. Conclusions Self-reported walking pace was inversely associated with risk of five cancer types, even when accounting for overall physical activity and walking volume. Adopting a brisk walking pace may represent a pragmatic target for public health interventions to decrease cancer risk, particularly in circumstances where increases in walking volume or frequency prove impractical. |
| format | Article |
| id | doaj-art-17a7d5ffbca74715a6ba39c78bfc2d84 |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-17a7d5ffbca74715a6ba39c78bfc2d842025-08-20T03:53:58ZengBMCBMC Cancer1471-24072025-05-012511910.1186/s12885-025-14258-xUsual walking Pace and risk of 28 cancers– results from the UK biobankMichael J. Stein0Hansjörg Baurecht1Patricia Bohmann2Pietro Ferrari3Béatrice Fervers4Emma Fontvieille5Heinz Freisling6Christine M. Friedenreich7Marc J. Gunter8Laia Peruchet-Noray9Anja M. Sedlmeier10Andrea Weber11Michael F. Leitzmann12Julian Konzok13Department of Epidemiology and Preventive Medicine, University of RegensburgDepartment of Epidemiology and Preventive Medicine, University of RegensburgDepartment of Epidemiology and Preventive Medicine, University of RegensburgNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO)Department of Prevention Cancer Environment, Centre Léon BérardNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO)Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO)Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health ServicesNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO)Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO)Department of Epidemiology and Preventive Medicine, University of RegensburgDepartment of Epidemiology and Preventive Medicine, University of RegensburgDepartment of Epidemiology and Preventive Medicine, University of RegensburgDepartment of Epidemiology and Preventive Medicine, University of RegensburgAbstract Background Usual walking pace represents a practical indicator of overall health. However, its association with cancer development remains unexplored. We investigated the relation between self-reported walking pace and cancer risk. Methods Using baseline UK Biobank data from 2006 to 2010, excluding the first two years of follow-up to reduce reverse causation, we employed multivariable Cox regression to assess the association between walking pace (slow, steady average, brisk) and risk of 28 cancer types, accounting for overall physical activity and walking volume. Results After a median follow-up of 10.9 years (interquartile range 10.1–11.8), 8.3% of 334,924 participants received a cancer diagnosis. Brisk compared to slow walking pace was associated with multivariable-adjusted lower risks of five cancers, including anal (hazard ratio 0.30; 95% confidence interval: 0.14–0.63), hepatocellular carcinoma (0.39; 0.23–0.66), small intestine (0.46; 0.24–0.87), thyroid (0.50; 0.29–0.86), and lung cancer (0.60; 0.51–0.70). Our findings were consistent across various sensitivity analyses, which assessed sex and age differences, residual confounding, and reverse causation. Conclusions Self-reported walking pace was inversely associated with risk of five cancer types, even when accounting for overall physical activity and walking volume. Adopting a brisk walking pace may represent a pragmatic target for public health interventions to decrease cancer risk, particularly in circumstances where increases in walking volume or frequency prove impractical.https://doi.org/10.1186/s12885-025-14258-xWalking PaceCancer preventionUK biobank |
| spellingShingle | Michael J. Stein Hansjörg Baurecht Patricia Bohmann Pietro Ferrari Béatrice Fervers Emma Fontvieille Heinz Freisling Christine M. Friedenreich Marc J. Gunter Laia Peruchet-Noray Anja M. Sedlmeier Andrea Weber Michael F. Leitzmann Julian Konzok Usual walking Pace and risk of 28 cancers– results from the UK biobank BMC Cancer Walking Pace Cancer prevention UK biobank |
| title | Usual walking Pace and risk of 28 cancers– results from the UK biobank |
| title_full | Usual walking Pace and risk of 28 cancers– results from the UK biobank |
| title_fullStr | Usual walking Pace and risk of 28 cancers– results from the UK biobank |
| title_full_unstemmed | Usual walking Pace and risk of 28 cancers– results from the UK biobank |
| title_short | Usual walking Pace and risk of 28 cancers– results from the UK biobank |
| title_sort | usual walking pace and risk of 28 cancers results from the uk biobank |
| topic | Walking Pace Cancer prevention UK biobank |
| url | https://doi.org/10.1186/s12885-025-14258-x |
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