The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients
Objective Myeloma-related bone disease (MBD) is one of the most common complications of multiple myeloma (MM). This study aims to investigate the correlation between serum bone metabolism indexes (BMIs), the clinical characteristics and prognosis of newly diagnosed MM (NDMM) patients. Methods: The s...
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2403205 |
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| author | Linlin Huang Yi Zhong Qingxiao Chen Donghua He Gaofeng Zheng Yang Yang Xiaoyan Han Wenjun Wu Yi Zhao Yi Li Li Yang Zhen Cai Jingsong He |
| author_facet | Linlin Huang Yi Zhong Qingxiao Chen Donghua He Gaofeng Zheng Yang Yang Xiaoyan Han Wenjun Wu Yi Zhao Yi Li Li Yang Zhen Cai Jingsong He |
| author_sort | Linlin Huang |
| collection | DOAJ |
| description | Objective Myeloma-related bone disease (MBD) is one of the most common complications of multiple myeloma (MM). This study aims to investigate the correlation between serum bone metabolism indexes (BMIs), the clinical characteristics and prognosis of newly diagnosed MM (NDMM) patients. Methods: The serum BMIs of 148 patients with NDMM in a single hematological disease treatment center from April 2014 to December 2019 were analyzed retrospectively, including type I collagen amino terminal elongation peptide (PINP), β-C-terminal telopeptide of type I collagen (β-CTX) and N-terminal osteocalcin (N-MID). Other clinical indexes were simultaneously collected and the degree of bone damage in patients was evaluated. We explored the effect of serum BMIs on the prognosis and identified independent prognostic factors. Another 77 NDMM patients from April 2018 to February 2021 served as the validation cohort. Results: The area under the curve (AUC) predicted by β-C-terminal telopeptide of type I collagen (β-CTX), type I collagen amino terminal elongation peptide (PINP), and N-terminal osteocalcin (N-MID) for overall survival (OS) were 0.708, 0.613, and 0.538, respectively. Patients with high serum levels had shorter OS (p < .001, p = .004, p = .027, respectively). Cox multivariate analysis indicated that serum β- CTX、lactic dehydrogenase、hemoglobin and the degree of bone injury were independent prognostic factors. A COX regression model was established with a C-index of 0.782 and validated with a C-index of 0.711. Conclusion: The serum BMIs are correlated with the patients’ OS, and β- CTX can be an independent prognostic factor. |
| format | Article |
| id | doaj-art-17a431c44a1a4f3d9c1b3045dd37dacb |
| institution | DOAJ |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-17a431c44a1a4f3d9c1b3045dd37dacb2025-08-20T02:49:46ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2403205The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patientsLinlin Huang0Yi Zhong1Qingxiao Chen2Donghua He3Gaofeng Zheng4Yang Yang5Xiaoyan Han6Wenjun Wu7Yi Zhao8Yi Li9Li Yang10Zhen Cai11Jingsong He12Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaObjective Myeloma-related bone disease (MBD) is one of the most common complications of multiple myeloma (MM). This study aims to investigate the correlation between serum bone metabolism indexes (BMIs), the clinical characteristics and prognosis of newly diagnosed MM (NDMM) patients. Methods: The serum BMIs of 148 patients with NDMM in a single hematological disease treatment center from April 2014 to December 2019 were analyzed retrospectively, including type I collagen amino terminal elongation peptide (PINP), β-C-terminal telopeptide of type I collagen (β-CTX) and N-terminal osteocalcin (N-MID). Other clinical indexes were simultaneously collected and the degree of bone damage in patients was evaluated. We explored the effect of serum BMIs on the prognosis and identified independent prognostic factors. Another 77 NDMM patients from April 2018 to February 2021 served as the validation cohort. Results: The area under the curve (AUC) predicted by β-C-terminal telopeptide of type I collagen (β-CTX), type I collagen amino terminal elongation peptide (PINP), and N-terminal osteocalcin (N-MID) for overall survival (OS) were 0.708, 0.613, and 0.538, respectively. Patients with high serum levels had shorter OS (p < .001, p = .004, p = .027, respectively). Cox multivariate analysis indicated that serum β- CTX、lactic dehydrogenase、hemoglobin and the degree of bone injury were independent prognostic factors. A COX regression model was established with a C-index of 0.782 and validated with a C-index of 0.711. Conclusion: The serum BMIs are correlated with the patients’ OS, and β- CTX can be an independent prognostic factor.https://www.tandfonline.com/doi/10.1080/15384047.2024.2403205Multiple myelomabone metabolism indexesmyeloma bone diseaseβ-CTXPINPN-MID |
| spellingShingle | Linlin Huang Yi Zhong Qingxiao Chen Donghua He Gaofeng Zheng Yang Yang Xiaoyan Han Wenjun Wu Yi Zhao Yi Li Li Yang Zhen Cai Jingsong He The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients Cancer Biology & Therapy Multiple myeloma bone metabolism indexes myeloma bone disease β-CTX PINP N-MID |
| title | The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients |
| title_full | The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients |
| title_fullStr | The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients |
| title_full_unstemmed | The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients |
| title_short | The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients |
| title_sort | correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients |
| topic | Multiple myeloma bone metabolism indexes myeloma bone disease β-CTX PINP N-MID |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2403205 |
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