Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responses

Esketamine attenuates traumatic brain injury by modulating STAT3-mediated Glycolysis and immune responses

Abstract Background Secondary injury following traumatic brain injury (TBI) involves neuroinflammation, immune cell infiltration, and metabolic dysregulation, leading to progressive neurological damage. This study evaluates the potential of esketamine, an NMDA receptor antagonist, to modulate immune...

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Bibliographic Details
Main Authors: Yufang Liu, Zheng Gong, Longfei Zhang, Xian Yang, Jie Zhu, Xin Zhou, Xingzhi Liao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Neuroscience
Subjects:
Traumatic brain injury
Esketamine
STAT3
Immune modulation
Glycolysis
Online Access:https://doi.org/10.1186/s12868-025-00941-z
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