Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis

Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis

IntroductionThis study aims to investigate the progressive impact of chronic iron overload on the olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson’s and Alzheimer’s. The focus is on understanding how iron accumulation leads to oxidative stress, mitoc...

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Bibliographic Details
Main Authors: Lin Deng, Qihui Luo, Yucong Liu, Yao Wang, Zongliang Xiong, Hongping Wang, Lu Zhao, Lanlan Jia, Riyi Shi, Chao Huang, Zhengli Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
iron overload
mice
lipid peroxidation
olfactory
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1506944/full
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