Molecular mechanisms and targeted therapy of progranulin in metabolic diseases

Molecular mechanisms and targeted therapy of progranulin in metabolic diseases

Progranulin (PGRN) is a secreted glycoprotein with cytokine-like properties, exerting tripartite mechanisms of inflammation suppression, tissue repair promotion, and metabolic regulation. This multifaceted functionality positions PGRN as a potential “multi-effect therapeutic strategy” for metabolic...

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Bibliographic Details
Main Authors: Xiaxia Wang, Yonglin Liang, Fan Yang, Yangyang Shi, Ruiwen Shao, Ruge Jing, Tong Yang, Qiao Chu, Dong An, Qi Zhou, Jiayi Song, Haolan Chen, Chun Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Endocrinology
Subjects:
PGRN
metabolic diseases
inflammation
cartilage repair
bone homeostasis
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1553794/full
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