Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function
Disseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate pyroptosis and then release interleukin (IL)-1β and...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Medical Journal of Peking Union Medical College Hospital
2024-11-01
|
| Series: | Xiehe Yixue Zazhi |
| Subjects: | |
| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0012 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850118211610083328 |
|---|---|
| author | GAO Jiawei DENG Xinkai HAN Xiaobo LI Xiao CHAI Yahao ZHANG Lei |
| author_facet | GAO Jiawei DENG Xinkai HAN Xiaobo LI Xiao CHAI Yahao ZHANG Lei |
| author_sort | GAO Jiawei |
| collection | DOAJ |
| description | Disseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate pyroptosis and then release interleukin (IL)-1β and IL-18, which further activates platelets and the coagulation system and exacerbates inflammatory responses and coagulation processes, thus creating great uncertainty for the treatment and prognosis of sepsis. This article aims to review the correlation between the inflammasome and pyroptosis, as well as their impact on coagulation function, in hope of providing new insights for the clinical treatment of DIC. |
| format | Article |
| id | doaj-art-178e023320f24ef988d2a495d6975231 |
| institution | OA Journals |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-178e023320f24ef988d2a495d69752312025-08-20T02:35:56ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812024-11-011561395140010.12290/xhyxzz.2024-0012Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation FunctionGAO Jiawei0DENG Xinkai1HAN Xiaobo2LI Xiao3CHAI Yahao4ZHANG Lei5School of Postgraduates, Xinjiang Medical University, Urumqi 830054, ChinaDepartment of Emergency Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, ChinaDepartment of Emergency Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, ChinaDepartment of Emergency Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, ChinaDepartment of Emergency Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, ChinaDepartment of Emergency Medicine, General Hospital of Xinjiang Military Command, Urumqi 830000, ChinaDisseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate pyroptosis and then release interleukin (IL)-1β and IL-18, which further activates platelets and the coagulation system and exacerbates inflammatory responses and coagulation processes, thus creating great uncertainty for the treatment and prognosis of sepsis. This article aims to review the correlation between the inflammasome and pyroptosis, as well as their impact on coagulation function, in hope of providing new insights for the clinical treatment of DIC.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0012inflammasomenlrp3pyroptosiscoagulation disorder |
| spellingShingle | GAO Jiawei DENG Xinkai HAN Xiaobo LI Xiao CHAI Yahao ZHANG Lei Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function Xiehe Yixue Zazhi inflammasome nlrp3 pyroptosis coagulation disorder |
| title | Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function |
| title_full | Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function |
| title_fullStr | Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function |
| title_full_unstemmed | Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function |
| title_short | Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function |
| title_sort | correlation of inflammasomes with pyroptosis and effect on coagulation function |
| topic | inflammasome nlrp3 pyroptosis coagulation disorder |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0012 |
| work_keys_str_mv | AT gaojiawei correlationofinflammasomeswithpyroptosisandeffectoncoagulationfunction AT dengxinkai correlationofinflammasomeswithpyroptosisandeffectoncoagulationfunction AT hanxiaobo correlationofinflammasomeswithpyroptosisandeffectoncoagulationfunction AT lixiao correlationofinflammasomeswithpyroptosisandeffectoncoagulationfunction AT chaiyahao correlationofinflammasomeswithpyroptosisandeffectoncoagulationfunction AT zhanglei correlationofinflammasomeswithpyroptosisandeffectoncoagulationfunction |