Allergic diseases in children with primary immunodeficiencies
The aim of this study was to evaluate and compare the frequency of atopy and allergic disease in all groups of primary immunodeficiency (PID) patients. The study was done on 318 patients with PID between the ages of 6 months and 18 years. The patients and their parents were questioned regardi...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2014-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1313 |
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| author | Celal Özcan Ayşe Metin Mustafa Erkoçoğlu Can Naci Kocabaş |
| author_facet | Celal Özcan Ayşe Metin Mustafa Erkoçoğlu Can Naci Kocabaş |
| author_sort | Celal Özcan |
| collection | DOAJ |
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The aim of this study was to evaluate and compare the frequency of atopy and allergic disease in all groups of primary immunodeficiency (PID) patients. The study was done on 318 patients with PID between the ages of 6 months and 18 years. The patients and their parents were questioned regarding their histories of asthma and allergic disease. Within the study group, 82.4% of the patients had antibody deficiency, 10.4% combined immunodeficiency, 6.6% phagocyte number or function defect, and 0.6% complement deficiency. Patients with selective immunoglobulin (Ig)A deficiency had a more significant history of ever wheezing compared to those with IgG subclass deficiency (p=0.022). The frequency of current wheezing was higher in patients with antibody deficiency than in patients with combined immunodeficiency (p=0.049). In conclusion, patients with antibody deficiency, especially those with selective IgA deficiency, should be evaluated regarding asthma and allergic diseases if recurring respiratory symptoms are present.
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| format | Article |
| id | doaj-art-178bb3da70a743d0b9130b251c375d6f |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-178bb3da70a743d0b9130b251c375d6f2025-08-20T02:55:39ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212014-02-01561Allergic diseases in children with primary immunodeficienciesCelal Özcan0Ayşe MetinMustafa ErkoçoğluCan Naci KocabaşDivision of Pediatric Immunology and Allergy, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara, Turkey. celalozcan01@yahoo.com.tr. The aim of this study was to evaluate and compare the frequency of atopy and allergic disease in all groups of primary immunodeficiency (PID) patients. The study was done on 318 patients with PID between the ages of 6 months and 18 years. The patients and their parents were questioned regarding their histories of asthma and allergic disease. Within the study group, 82.4% of the patients had antibody deficiency, 10.4% combined immunodeficiency, 6.6% phagocyte number or function defect, and 0.6% complement deficiency. Patients with selective immunoglobulin (Ig)A deficiency had a more significant history of ever wheezing compared to those with IgG subclass deficiency (p=0.022). The frequency of current wheezing was higher in patients with antibody deficiency than in patients with combined immunodeficiency (p=0.049). In conclusion, patients with antibody deficiency, especially those with selective IgA deficiency, should be evaluated regarding asthma and allergic diseases if recurring respiratory symptoms are present. https://turkjpediatr.org/article/view/1313 |
| spellingShingle | Celal Özcan Ayşe Metin Mustafa Erkoçoğlu Can Naci Kocabaş Allergic diseases in children with primary immunodeficiencies The Turkish Journal of Pediatrics |
| title | Allergic diseases in children with primary immunodeficiencies |
| title_full | Allergic diseases in children with primary immunodeficiencies |
| title_fullStr | Allergic diseases in children with primary immunodeficiencies |
| title_full_unstemmed | Allergic diseases in children with primary immunodeficiencies |
| title_short | Allergic diseases in children with primary immunodeficiencies |
| title_sort | allergic diseases in children with primary immunodeficiencies |
| url | https://turkjpediatr.org/article/view/1313 |
| work_keys_str_mv | AT celalozcan allergicdiseasesinchildrenwithprimaryimmunodeficiencies AT aysemetin allergicdiseasesinchildrenwithprimaryimmunodeficiencies AT mustafaerkocoglu allergicdiseasesinchildrenwithprimaryimmunodeficiencies AT cannacikocabas allergicdiseasesinchildrenwithprimaryimmunodeficiencies |