Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research
Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translationa...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/9605252 |
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| _version_ | 1850234840479170560 |
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| author | Jingjing Wang Bingqian Qu Fang Zhang Cindy Zhang Wanyan Deng Viet Loan Dao Thi Yuchen Xia |
| author_facet | Jingjing Wang Bingqian Qu Fang Zhang Cindy Zhang Wanyan Deng Viet Loan Dao Thi Yuchen Xia |
| author_sort | Jingjing Wang |
| collection | DOAJ |
| description | Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translational research on viral hepatitis has been performed for many years, conventional hepatocellular culture systems are not optimal. These studies have greatly benefited from recent efforts on improving cell culture models for virus replication and infection studies. Here we summarize the use of human stem cell-derived hepatocyte-like cells for hepatotropic virus infection studies, including the dissection of virus-host interactions and virus-induced pathogenesis as well as the identification and validation of novel antiviral agents. |
| format | Article |
| id | doaj-art-178a547ad65a4d6281a58cc8e4783b46 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-178a547ad65a4d6281a58cc8e4783b462025-08-20T02:02:30ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/96052529605252Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis ResearchJingjing Wang0Bingqian Qu1Fang Zhang2Cindy Zhang3Wanyan Deng4Viet Loan Dao Thi5Yuchen Xia6State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaDepartment of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Translational Medicine, Baruch S. Blumberg Institute, Doylestown, PA, USASchaller Research Group at Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks, Heidelberg, GermanyKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaSchaller Research Group at Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks, Heidelberg, GermanyState Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, ChinaViral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translational research on viral hepatitis has been performed for many years, conventional hepatocellular culture systems are not optimal. These studies have greatly benefited from recent efforts on improving cell culture models for virus replication and infection studies. Here we summarize the use of human stem cell-derived hepatocyte-like cells for hepatotropic virus infection studies, including the dissection of virus-host interactions and virus-induced pathogenesis as well as the identification and validation of novel antiviral agents.http://dx.doi.org/10.1155/2019/9605252 |
| spellingShingle | Jingjing Wang Bingqian Qu Fang Zhang Cindy Zhang Wanyan Deng Viet Loan Dao Thi Yuchen Xia Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research Stem Cells International |
| title | Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research |
| title_full | Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research |
| title_fullStr | Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research |
| title_full_unstemmed | Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research |
| title_short | Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research |
| title_sort | stem cell derived hepatocyte like cells as model for viral hepatitis research |
| url | http://dx.doi.org/10.1155/2019/9605252 |
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