Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study
Abstract Background Previous studies have reported that anemia was associated with depression, but the association between changes in depressive symptoms and the risk of anemia was unclear. This study aimed to explore whether changes in depressive symptoms were associated with anemia among the middl...
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2024-10-01
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| Online Access: | https://doi.org/10.1186/s13690-024-01390-6 |
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| author | Yucong Bi Liping Zheng Leping Zhang Longyang Han Yang Liu Xiaowei Zheng Chongke Zhong |
| author_facet | Yucong Bi Liping Zheng Leping Zhang Longyang Han Yang Liu Xiaowei Zheng Chongke Zhong |
| author_sort | Yucong Bi |
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| description | Abstract Background Previous studies have reported that anemia was associated with depression, but the association between changes in depressive symptoms and the risk of anemia was unclear. This study aimed to explore whether changes in depressive symptoms were associated with anemia among the middle-aged and elderly adults. Methods A total of 6112 patients aged 45 years and older from the China Health and Retirement Longitudinal Study (CHARLS) were included in this analysis. Elevated Depression Symptoms (EDS) was defined as the Center for Epidemiological Studies Depression Scale-10 score ≥ 10. Depression status was defined as no depressive symptom [no EDS at Wave 1 (2011–2012) and Wave 2 (2013–2014)], decreasing depressive symptoms (EDS at Wave 1, no EDS at Wave 2), increasing depressive symptoms (no EDS at Wave 1, EDS at Wave 2), persistent depressive symptoms (EDS at Wave 1 and Wave 2). Multivariable logistic regression analyses were conducted to estimate the relationships between depressive symptoms and the changes and risk of anemia. Results During the follow-up of Wave 1 and Wave 3 (2015–2016), 906 participants (14.82%) developed anemia, the multivariable-adjusted odds ratio for the depressive symptom compared with the no depressive symptom was 1.24 (95% CI, 1.12–1.58) for anemia. From Wave 2 to Wave 3, there were 828 participants (14.62%) diagnosed with anemia. Compared to participants with no depressive symptom, those with persistent depressive symptoms during Wave 1 and Wave 2 had the significantly elevated risk of anemia (odds ratio 1.44, 95% CI 1.21–1.84). Conclusions The present study demonstrated that baseline depressive symptoms and changes in depressive symptoms were associated with increased risks of anemia. |
| format | Article |
| id | doaj-art-17874d21e95d4e0d963245ff0055d1df |
| institution | OA Journals |
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| language | English |
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| publisher | BMC |
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| series | Archives of Public Health |
| spelling | doaj-art-17874d21e95d4e0d963245ff0055d1df2025-08-20T02:17:41ZengBMCArchives of Public Health2049-32582024-10-018211910.1186/s13690-024-01390-6Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal studyYucong Bi0Liping Zheng1Leping Zhang2Longyang Han3Yang Liu4Xiaowei Zheng5Chongke Zhong6Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow UniversityDepartment of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow UniversityDepartment of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow UniversityPublic Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan UniversityDepartment of Cardiology, First Affiliated Hospital of Soochow UniversityPublic Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan UniversityDepartment of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow UniversityAbstract Background Previous studies have reported that anemia was associated with depression, but the association between changes in depressive symptoms and the risk of anemia was unclear. This study aimed to explore whether changes in depressive symptoms were associated with anemia among the middle-aged and elderly adults. Methods A total of 6112 patients aged 45 years and older from the China Health and Retirement Longitudinal Study (CHARLS) were included in this analysis. Elevated Depression Symptoms (EDS) was defined as the Center for Epidemiological Studies Depression Scale-10 score ≥ 10. Depression status was defined as no depressive symptom [no EDS at Wave 1 (2011–2012) and Wave 2 (2013–2014)], decreasing depressive symptoms (EDS at Wave 1, no EDS at Wave 2), increasing depressive symptoms (no EDS at Wave 1, EDS at Wave 2), persistent depressive symptoms (EDS at Wave 1 and Wave 2). Multivariable logistic regression analyses were conducted to estimate the relationships between depressive symptoms and the changes and risk of anemia. Results During the follow-up of Wave 1 and Wave 3 (2015–2016), 906 participants (14.82%) developed anemia, the multivariable-adjusted odds ratio for the depressive symptom compared with the no depressive symptom was 1.24 (95% CI, 1.12–1.58) for anemia. From Wave 2 to Wave 3, there were 828 participants (14.62%) diagnosed with anemia. Compared to participants with no depressive symptom, those with persistent depressive symptoms during Wave 1 and Wave 2 had the significantly elevated risk of anemia (odds ratio 1.44, 95% CI 1.21–1.84). Conclusions The present study demonstrated that baseline depressive symptoms and changes in depressive symptoms were associated with increased risks of anemia.https://doi.org/10.1186/s13690-024-01390-6Depressive symptomsAnemiaDynamic changesMiddle-aged and older Chinese adults |
| spellingShingle | Yucong Bi Liping Zheng Leping Zhang Longyang Han Yang Liu Xiaowei Zheng Chongke Zhong Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study Archives of Public Health Depressive symptoms Anemia Dynamic changes Middle-aged and older Chinese adults |
| title | Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study |
| title_full | Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study |
| title_fullStr | Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study |
| title_full_unstemmed | Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study |
| title_short | Association between changes in depressive symptoms and risk of anemia: from the China Health and Retirement longitudinal study |
| title_sort | association between changes in depressive symptoms and risk of anemia from the china health and retirement longitudinal study |
| topic | Depressive symptoms Anemia Dynamic changes Middle-aged and older Chinese adults |
| url | https://doi.org/10.1186/s13690-024-01390-6 |
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