Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders
IntroductionIt is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. Dysfunctions in these systems can impact mental health by altering neurotransmitter levels and the neurochemical environmen...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1537442/full |
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| author | João Francisco Pollo Gaspary João Francisco Pollo Gaspary Luis Felipe Dias Lopes Antonio Geraldo Camara |
| author_facet | João Francisco Pollo Gaspary João Francisco Pollo Gaspary Luis Felipe Dias Lopes Antonio Geraldo Camara |
| author_sort | João Francisco Pollo Gaspary |
| collection | DOAJ |
| description | IntroductionIt is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. Dysfunctions in these systems can impact mental health by altering neurotransmitter levels and the neurochemical environment. This shift in understanding underscores the need for therapeutic strategies that address systemic health and mitochondrial function, alongside psychosocial aspects of the disease, offering a more personalized and adaptive approach to treatment.MethodologyThis study utilizes a translational research approach structured through the Work Breakdown Structure methodology, dividing the process into six interconnected Work Packages (WPs). These include systematic literature reviews on endocrine dysfunctions and hormonal therapies in mental disorders, application of Design Thinking for neuroendocrine innovation, and hypothesis exploration of hCG as a systemic adjunctive treatment for psychiatric disorders, culminating in result dissemination and evaluation.ResultsWork The study identified multiple mechanistic impacts of human chorionic gonadotropin (hCG) relevant to psychiatric treatment. Key findings from hCG Hormetic Therapy (HHT) include stimulation of sex hormone production, reduction of insulin resistance and systemic inflammation, enhancement of hypothalamic activity to regulate appetite, sleep, and emotions, and LH-like effects on cognition. HHT also increases IGF-1 availability, promoting neuroprotection, cognitive improvements, and reduced mitochondrial dysfunction, restoring cellular function critical for brain health.Implications for Clinical PracticeThe findings underscore the significance of enhancing endocrine and metabolic functions as a viable strategy for improving psychiatric care, aligning with trends that advocate holistic treatment strategies. The suggested dose for future research protocols is 500 IU IM per week for at least 10 weeks.ConclusionSupporting diverse and varied research is crucial for advancing medical knowledge. Continuous exploration of neuroendocrine dysfunctions in mental disorders using advanced tools from neuroscience, endocrinology, and psychiatry can provide new pathways for more effective and personalized treatments. The study of HHT effects offers insights into complex neuroendocrine interactions, underscoring the potential for innovative therapeutic strategies in psychiatry. |
| format | Article |
| id | doaj-art-177fad67f982404f9e86e7a71051e2f7 |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-177fad67f982404f9e86e7a71051e2f72025-08-20T02:19:34ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-04-011610.3389/fpsyt.2025.15374421537442Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disordersJoão Francisco Pollo Gaspary0João Francisco Pollo Gaspary1Luis Felipe Dias Lopes2Antonio Geraldo Camara3Instituto AuBento – Center for Teaching, Clinical Practice and Research in Orthomolecular and Translational Health Innovation, Santa Maria, BrazilFederal University of Santa Maria, Santa Maria, BrazilCenter for Social and Human Sciences, Postgraduate Program in Administration, Federal University of Santa Maria, Santa Maria, BrazilInstitute Camara – Center for Clinical and Orthomolecular Practice, Ribeirão Preto, BrazilIntroductionIt is increasingly recognized that the brain continuously interacts with other body systems such as the immune system, the gut-brain axis, and the endocrine system. Dysfunctions in these systems can impact mental health by altering neurotransmitter levels and the neurochemical environment. This shift in understanding underscores the need for therapeutic strategies that address systemic health and mitochondrial function, alongside psychosocial aspects of the disease, offering a more personalized and adaptive approach to treatment.MethodologyThis study utilizes a translational research approach structured through the Work Breakdown Structure methodology, dividing the process into six interconnected Work Packages (WPs). These include systematic literature reviews on endocrine dysfunctions and hormonal therapies in mental disorders, application of Design Thinking for neuroendocrine innovation, and hypothesis exploration of hCG as a systemic adjunctive treatment for psychiatric disorders, culminating in result dissemination and evaluation.ResultsWork The study identified multiple mechanistic impacts of human chorionic gonadotropin (hCG) relevant to psychiatric treatment. Key findings from hCG Hormetic Therapy (HHT) include stimulation of sex hormone production, reduction of insulin resistance and systemic inflammation, enhancement of hypothalamic activity to regulate appetite, sleep, and emotions, and LH-like effects on cognition. HHT also increases IGF-1 availability, promoting neuroprotection, cognitive improvements, and reduced mitochondrial dysfunction, restoring cellular function critical for brain health.Implications for Clinical PracticeThe findings underscore the significance of enhancing endocrine and metabolic functions as a viable strategy for improving psychiatric care, aligning with trends that advocate holistic treatment strategies. The suggested dose for future research protocols is 500 IU IM per week for at least 10 weeks.ConclusionSupporting diverse and varied research is crucial for advancing medical knowledge. Continuous exploration of neuroendocrine dysfunctions in mental disorders using advanced tools from neuroscience, endocrinology, and psychiatry can provide new pathways for more effective and personalized treatments. The study of HHT effects offers insights into complex neuroendocrine interactions, underscoring the potential for innovative therapeutic strategies in psychiatry.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1537442/fullpsychiatric disordershormetic therapyneuroplasticitysystemic inflammationinsulin resistancesex hormone production |
| spellingShingle | João Francisco Pollo Gaspary João Francisco Pollo Gaspary Luis Felipe Dias Lopes Antonio Geraldo Camara Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders Frontiers in Psychiatry psychiatric disorders hormetic therapy neuroplasticity systemic inflammation insulin resistance sex hormone production |
| title | Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders |
| title_full | Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders |
| title_fullStr | Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders |
| title_full_unstemmed | Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders |
| title_short | Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders |
| title_sort | translational interdisciplinary research on human chorionic gonadotropin s enhancement of neuroendocrine crosstalk a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders |
| topic | psychiatric disorders hormetic therapy neuroplasticity systemic inflammation insulin resistance sex hormone production |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1537442/full |
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