Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer

Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer

Abstract Nowadays, chemotherapy and immunotherapy remain the major treatment strategies for Triple-Negative Breast Cancer (TNBC). Identifying biomarkers to pre-select and subclassify TNBC patients with distinct chemotherapy responses is essential. In the current study, we performed an unbiased Rever...

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Bibliographic Details
Main Authors: Bohan Ning, Chang Liu, Ali Cem Kucukdagli, Jiuyi Zhang, Han Jing, Zhiqian Zhou, Yuwei Zhang, Ying Dong, Yunjia Chen, Hua Guo, Jia Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
TNBC
Cancer Disparity
AURKA
AURKB
Neoadjuvant Chemotherapy
Online Access:https://doi.org/10.1038/s41598-025-87315-x
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