Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response.

Although B cell depletion therapy (BCDT) is effective in a subset of rheumatoid arthritis (RA) patients, both mechanisms and biomarkers of response are poorly defined. Here we characterized abnormalities in B cell populations in RA and the impact of BCDT in order to elucidate B cell roles in the dis...

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Bibliographic Details
Main Authors: Diana G Adlowitz, Jennifer Barnard, Jamie N Biear, Christopher Cistrone, Teresa Owen, Wensheng Wang, Arumugam Palanichamy, Ezinma Ezealah, Debbie Campbell, Chungwen Wei, R John Looney, Inaki Sanz, Jennifer H Anolik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0128269
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