Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks
Abstract Hypoxic pulmonary hypertension (HPH) is a life‐threatening disease that occurs due to a lack of oxygen in the lungs, leading to an increase in pulmonary vascular resistance, right ventricular failure, and ultimately death. HPH is a multifactorial disorder that involves multiple molecular pa...
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Wiley
2023-07-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12138 |
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| author | Zhidan Hua Mingming Han Lanlan Song Yongle Yan Honglang Chen Jilong Wang Chao Li Yanfan Chen Hanhan Yan Mayun Chen |
| author_facet | Zhidan Hua Mingming Han Lanlan Song Yongle Yan Honglang Chen Jilong Wang Chao Li Yanfan Chen Hanhan Yan Mayun Chen |
| author_sort | Zhidan Hua |
| collection | DOAJ |
| description | Abstract Hypoxic pulmonary hypertension (HPH) is a life‐threatening disease that occurs due to a lack of oxygen in the lungs, leading to an increase in pulmonary vascular resistance, right ventricular failure, and ultimately death. HPH is a multifactorial disorder that involves multiple molecular pathways, making it a challenge for clinicians to identify effective therapies. Pulmonary artery smooth muscle cells (PASMCs) play a crucial role in HPH pathogenesis by proliferating, resisting apoptosis, and promoting vascular remodelling. Curcumin, a natural polyphenolic compound, has shown potential as a therapeutic agent for HPH by reducing pulmonary vascular resistance, inhibiting vascular remodelling, and promoting apoptosis of PASMCs. Regulation of PASMCs could significantly inhibits HPH. However, curcumin has the disadvantages of poor solubility and low bioavailability, and its derivative WZ35 has better biosafety. Here, Cu‐based metal organic frameworks (MOFCu) was fabricated to encapsulate the curcumin analogue WZ35 (MOFCu@WZ35) for the inhibition of PASMCs proliferation. The authors found that the MOFCu@WZ35 could promote the death of PASMCs. Furthermore, the authors believed that this drug delivery system will effectively alleviate the HPH. |
| format | Article |
| id | doaj-art-1775ea6da602407bbbfc3f9aaccca2fe |
| institution | DOAJ |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wiley |
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| series | IET Nanobiotechnology |
| spelling | doaj-art-1775ea6da602407bbbfc3f9aaccca2fe2025-08-20T03:17:04ZengWileyIET Nanobiotechnology1751-87411751-875X2023-07-0117542042410.1049/nbt2.12138Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworksZhidan Hua0Mingming Han1Lanlan Song2Yongle Yan3Honglang Chen4Jilong Wang5Chao Li6Yanfan Chen7Hanhan Yan8Mayun Chen9Department of Pulmonary and Critical Care Medicine The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital Quzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The Longgang People's Hospital Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The Longgang People's Hospital Wenzhou Medical University Wenzhou Zhejiang ChinaZhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital Quzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine Ruian People's Hospital The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaAbstract Hypoxic pulmonary hypertension (HPH) is a life‐threatening disease that occurs due to a lack of oxygen in the lungs, leading to an increase in pulmonary vascular resistance, right ventricular failure, and ultimately death. HPH is a multifactorial disorder that involves multiple molecular pathways, making it a challenge for clinicians to identify effective therapies. Pulmonary artery smooth muscle cells (PASMCs) play a crucial role in HPH pathogenesis by proliferating, resisting apoptosis, and promoting vascular remodelling. Curcumin, a natural polyphenolic compound, has shown potential as a therapeutic agent for HPH by reducing pulmonary vascular resistance, inhibiting vascular remodelling, and promoting apoptosis of PASMCs. Regulation of PASMCs could significantly inhibits HPH. However, curcumin has the disadvantages of poor solubility and low bioavailability, and its derivative WZ35 has better biosafety. Here, Cu‐based metal organic frameworks (MOFCu) was fabricated to encapsulate the curcumin analogue WZ35 (MOFCu@WZ35) for the inhibition of PASMCs proliferation. The authors found that the MOFCu@WZ35 could promote the death of PASMCs. Furthermore, the authors believed that this drug delivery system will effectively alleviate the HPH.https://doi.org/10.1049/nbt2.12138drug delivery systemsnanobiotechnologynanoparticlespulmonary hypertension |
| spellingShingle | Zhidan Hua Mingming Han Lanlan Song Yongle Yan Honglang Chen Jilong Wang Chao Li Yanfan Chen Hanhan Yan Mayun Chen Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks IET Nanobiotechnology drug delivery systems nanobiotechnology nanoparticles pulmonary hypertension |
| title | Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks |
| title_full | Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks |
| title_fullStr | Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks |
| title_full_unstemmed | Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks |
| title_short | Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks |
| title_sort | inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid wz35 by cu based metal organic frameworks |
| topic | drug delivery systems nanobiotechnology nanoparticles pulmonary hypertension |
| url | https://doi.org/10.1049/nbt2.12138 |
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