Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy
Abstract Hepatocellular carcinoma (HCC) remains a global health challenge owing to its widespread incidence and high mortality. HCC has a specific immune tolerance function because of its unique physiological structure, which limits the efficacy of chemotherapy, radiotherapy, and molecular targeting...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01747-5 |
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| author | Minni Zhang Kailin Huang Qiushi Yin Xueqin Wu Mingyue Zhu Mengsen Li |
| author_facet | Minni Zhang Kailin Huang Qiushi Yin Xueqin Wu Mingyue Zhu Mengsen Li |
| author_sort | Minni Zhang |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) remains a global health challenge owing to its widespread incidence and high mortality. HCC has a specific immune tolerance function because of its unique physiological structure, which limits the efficacy of chemotherapy, radiotherapy, and molecular targeting. In recent years, new immune approaches, including adoptive cell therapy, tumor vaccines, and oncolytic virus therapy, have shown great potential. As the efficacy of immunotherapy mainly depends on the spatial heterogeneity of the tumor immune microenvironment, it is necessary to elucidate the crosstalk between the composition of the liver cancer immune environment, from which potential therapeutic targets can be selected to provide more appropriate individualized treatment programs. The role of spatial heterogeneity of immune cells in the microenvironment of HCC in the progression and influence of immunotherapy on improving the treatment and prognosis of HCC were comprehensively analyzed, providing new inspiration for the subsequent clinical treatment of liver cancer. |
| format | Article |
| id | doaj-art-177343f783b848f5b6a534787dfc4915 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-177343f783b848f5b6a534787dfc49152025-01-12T12:29:10ZengSpringerDiscover Oncology2730-60112025-01-0116112110.1007/s12672-025-01747-5Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapyMinni Zhang0Kailin Huang1Qiushi Yin2Xueqin Wu3Mingyue Zhu4Mengsen Li5Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical UniversityHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical UniversityHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical UniversityHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical UniversityHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical UniversityHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical UniversityAbstract Hepatocellular carcinoma (HCC) remains a global health challenge owing to its widespread incidence and high mortality. HCC has a specific immune tolerance function because of its unique physiological structure, which limits the efficacy of chemotherapy, radiotherapy, and molecular targeting. In recent years, new immune approaches, including adoptive cell therapy, tumor vaccines, and oncolytic virus therapy, have shown great potential. As the efficacy of immunotherapy mainly depends on the spatial heterogeneity of the tumor immune microenvironment, it is necessary to elucidate the crosstalk between the composition of the liver cancer immune environment, from which potential therapeutic targets can be selected to provide more appropriate individualized treatment programs. The role of spatial heterogeneity of immune cells in the microenvironment of HCC in the progression and influence of immunotherapy on improving the treatment and prognosis of HCC were comprehensively analyzed, providing new inspiration for the subsequent clinical treatment of liver cancer.https://doi.org/10.1007/s12672-025-01747-5Hepatocellular carcinomaSpatial heterogeneityTumor microenvironmentImmunotherapy |
| spellingShingle | Minni Zhang Kailin Huang Qiushi Yin Xueqin Wu Mingyue Zhu Mengsen Li Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy Discover Oncology Hepatocellular carcinoma Spatial heterogeneity Tumor microenvironment Immunotherapy |
| title | Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy |
| title_full | Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy |
| title_fullStr | Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy |
| title_full_unstemmed | Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy |
| title_short | Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy |
| title_sort | spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy |
| topic | Hepatocellular carcinoma Spatial heterogeneity Tumor microenvironment Immunotherapy |
| url | https://doi.org/10.1007/s12672-025-01747-5 |
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