Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up
We wanted to identify in children with epilepsy the factors associated with seizure control and recurrence after a 2-year remission. Methods: We did a 5-year follow-up of epileptic children whose antiepileptic medication had been stopped. Bivariate and multivariate analyses were used to compare feat...
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Elsevier
2017-08-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957216303710 |
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| author | Inn-Chi Lee Shuan-Yow Li Yung-Jung Chen |
| author_facet | Inn-Chi Lee Shuan-Yow Li Yung-Jung Chen |
| author_sort | Inn-Chi Lee |
| collection | DOAJ |
| description | We wanted to identify in children with epilepsy the factors associated with seizure control and recurrence after a 2-year remission.
Methods: We did a 5-year follow-up of epileptic children whose antiepileptic medication had been stopped. Bivariate and multivariate analyses were used to compare features of electroencephalograms (EEGs) and clinical findings. In this study, 43 patients with and 64 without a seizure recurrence (SR) were enrolled.
Results: Clinical features strongly associated with SR in the univariate analysis included a symptomatic etiology for seizures, a history of status epilepticus, treatment duration before stopping antiepileptic drugs, and abnormal EEG findings at the time of stopping antiepileptic drugs.
Conclusion: We found that a history of status epilepticus, symptomatic partial epilepsy, treatment duration before stopping antiepileptic drugs, and an abnormal EEG when the medication was stopped are important predictors of SR. The risk factors of SR after discontinuing antiepileptic drugs have been investigated in several studies. However, a history of status epilepticus as a predictive factor is rarely mentioned. |
| format | Article |
| id | doaj-art-1770064209314157abe0c5fa9efc83a4 |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-1770064209314157abe0c5fa9efc83a42025-08-20T02:25:48ZengElsevierPediatrics and Neonatology1875-95722017-08-0158433834310.1016/j.pedneo.2016.08.005Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-UpInn-Chi Lee0Shuan-Yow Li1Yung-Jung Chen2Division of Pediatric Neurology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, TaiwanInstitute of Medicine, School of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Pediatrics, College of Medicine, National Cheng Kung University Hospital, Tainan, TaiwanWe wanted to identify in children with epilepsy the factors associated with seizure control and recurrence after a 2-year remission. Methods: We did a 5-year follow-up of epileptic children whose antiepileptic medication had been stopped. Bivariate and multivariate analyses were used to compare features of electroencephalograms (EEGs) and clinical findings. In this study, 43 patients with and 64 without a seizure recurrence (SR) were enrolled. Results: Clinical features strongly associated with SR in the univariate analysis included a symptomatic etiology for seizures, a history of status epilepticus, treatment duration before stopping antiepileptic drugs, and abnormal EEG findings at the time of stopping antiepileptic drugs. Conclusion: We found that a history of status epilepticus, symptomatic partial epilepsy, treatment duration before stopping antiepileptic drugs, and an abnormal EEG when the medication was stopped are important predictors of SR. The risk factors of SR after discontinuing antiepileptic drugs have been investigated in several studies. However, a history of status epilepticus as a predictive factor is rarely mentioned.http://www.sciencedirect.com/science/article/pii/S1875957216303710antiepileptic drugchildrenepilepsyoutcomerecurrenceremission |
| spellingShingle | Inn-Chi Lee Shuan-Yow Li Yung-Jung Chen Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up Pediatrics and Neonatology antiepileptic drug children epilepsy outcome recurrence remission |
| title | Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up |
| title_full | Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up |
| title_fullStr | Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up |
| title_full_unstemmed | Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up |
| title_short | Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up |
| title_sort | seizure recurrence in children after stopping antiepileptic medication 5 year follow up |
| topic | antiepileptic drug children epilepsy outcome recurrence remission |
| url | http://www.sciencedirect.com/science/article/pii/S1875957216303710 |
| work_keys_str_mv | AT innchilee seizurerecurrenceinchildrenafterstoppingantiepilepticmedication5yearfollowup AT shuanyowli seizurerecurrenceinchildrenafterstoppingantiepilepticmedication5yearfollowup AT yungjungchen seizurerecurrenceinchildrenafterstoppingantiepilepticmedication5yearfollowup |