Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study
BACKGROUND: The prevalence of obesity, or an excessive fat accumulation, is keep increasing. In obesity, inflammation can be induced by leaky gut due to the intestinal tight junction barrier dysfunction. Zonula occludens-1 (ZO-1) plays a role in developing intestinal tight junction barrier dysfuncti...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Secretariat of The Indonesian Biomedical Journal
2024-10-01
|
| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/3250 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850285037743767552 |
|---|---|
| author | Armanto Makmun Agussalim Bukhari Nurpudji Astuti Taslim Aminuddin Aminuddin Ferry Sandra |
| author_facet | Armanto Makmun Agussalim Bukhari Nurpudji Astuti Taslim Aminuddin Aminuddin Ferry Sandra |
| author_sort | Armanto Makmun |
| collection | DOAJ |
| description | BACKGROUND: The prevalence of obesity, or an excessive fat accumulation, is keep increasing. In obesity, inflammation can be induced by leaky gut due to the intestinal tight junction barrier dysfunction. Zonula occludens-1 (ZO-1) plays a role in developing intestinal tight junction barrier dysfunction and gut microbiota imbalance, thus promote the translocation of bacterial endotoxin characterized by lipopolysaccharide (LPS) into circulation. Black rice extract (BRE) has been known to have anti-inflammatory property. This study was conducted to investigate the effect of BRE on body weight (BW), waist circumference (WC), body mass index (BMI), ZO-1 and LPS of obese patients.
METHODS: Twenty-three male subjects were divided into non-obese group (NOG), obese group (COG) and BRE-obese group (BOG). Subjects in BOG received a daily dose of 5.6 g/day BRE for 4 weeks. BW, WC and BMI, serum ZO-1 and LPS were measured before and after treatment.
RESULTS: BRE was prepared successfully and free from microbial contamination. Treatment of BRE for 4 weeks reduce BW (95.40±5.78 vs. 94.59±6.00 kg, p=0.043), WC (109.25±3.55 vs. 107.50±3.46 cm, p=0.000) BMI (32.65±1.86 vs. 32.18±1.80, p=0.000) and LPS (222.27±38.63 vs. 131.63±9.70 ng/mL, p=0.020) of obese subjects. The pre-post ZO-1 levels in all groups were not significantly different (p>0.05).
CONCLUSION: Treatment of 5.6 gr BRE daily for four weeks can reduce BW, WC, BMI and serum LPS, but not serum ZO-1 in obese patients. Therefore, BRE may reduce inflammation in obesity.
KEYWORDS: black rice, obesity, BW, WC, BMI, LPS, ZO-1 |
| format | Article |
| id | doaj-art-176ebffbc24a446a845e4c4ba022d5e3 |
| institution | OA Journals |
| issn | 2085-3297 2355-9179 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj-art-176ebffbc24a446a845e4c4ba022d5e32025-08-20T01:47:25ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792024-10-011654596310.18585/inabj.v16i5.3250599Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary StudyArmanto Makmun0Agussalim Bukhari1Nurpudji Astuti Taslim2Aminuddin Aminuddin3Ferry Sandra4Faculty of Medicine, Moslem Universitas Muslim Indonesia, Jl. Urip Sumoharjo Km.5, Makassar 90231Department of Nutrition, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km.10, Makassar 90245Department of Nutrition, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km.10, Makassar 90245Department of Nutrition, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan Km.10, Makassar 90245Department of Biochemistry and Molecular Biology, Division of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jl. Kyai Tapa No. 260, Jakarta 11440BACKGROUND: The prevalence of obesity, or an excessive fat accumulation, is keep increasing. In obesity, inflammation can be induced by leaky gut due to the intestinal tight junction barrier dysfunction. Zonula occludens-1 (ZO-1) plays a role in developing intestinal tight junction barrier dysfunction and gut microbiota imbalance, thus promote the translocation of bacterial endotoxin characterized by lipopolysaccharide (LPS) into circulation. Black rice extract (BRE) has been known to have anti-inflammatory property. This study was conducted to investigate the effect of BRE on body weight (BW), waist circumference (WC), body mass index (BMI), ZO-1 and LPS of obese patients. METHODS: Twenty-three male subjects were divided into non-obese group (NOG), obese group (COG) and BRE-obese group (BOG). Subjects in BOG received a daily dose of 5.6 g/day BRE for 4 weeks. BW, WC and BMI, serum ZO-1 and LPS were measured before and after treatment. RESULTS: BRE was prepared successfully and free from microbial contamination. Treatment of BRE for 4 weeks reduce BW (95.40±5.78 vs. 94.59±6.00 kg, p=0.043), WC (109.25±3.55 vs. 107.50±3.46 cm, p=0.000) BMI (32.65±1.86 vs. 32.18±1.80, p=0.000) and LPS (222.27±38.63 vs. 131.63±9.70 ng/mL, p=0.020) of obese subjects. The pre-post ZO-1 levels in all groups were not significantly different (p>0.05). CONCLUSION: Treatment of 5.6 gr BRE daily for four weeks can reduce BW, WC, BMI and serum LPS, but not serum ZO-1 in obese patients. Therefore, BRE may reduce inflammation in obesity. KEYWORDS: black rice, obesity, BW, WC, BMI, LPS, ZO-1https://inabj.org/index.php/ibj/article/view/3250 |
| spellingShingle | Armanto Makmun Agussalim Bukhari Nurpudji Astuti Taslim Aminuddin Aminuddin Ferry Sandra Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study Indonesian Biomedical Journal |
| title | Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study |
| title_full | Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study |
| title_fullStr | Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study |
| title_full_unstemmed | Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study |
| title_short | Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study |
| title_sort | black rice extract reduces body weight waist circumference body mass index and lipopolysaccharide in obese subjects a preliminary study |
| url | https://inabj.org/index.php/ibj/article/view/3250 |
| work_keys_str_mv | AT armantomakmun blackriceextractreducesbodyweightwaistcircumferencebodymassindexandlipopolysaccharideinobesesubjectsapreliminarystudy AT agussalimbukhari blackriceextractreducesbodyweightwaistcircumferencebodymassindexandlipopolysaccharideinobesesubjectsapreliminarystudy AT nurpudjiastutitaslim blackriceextractreducesbodyweightwaistcircumferencebodymassindexandlipopolysaccharideinobesesubjectsapreliminarystudy AT aminuddinaminuddin blackriceextractreducesbodyweightwaistcircumferencebodymassindexandlipopolysaccharideinobesesubjectsapreliminarystudy AT ferrysandra blackriceextractreducesbodyweightwaistcircumferencebodymassindexandlipopolysaccharideinobesesubjectsapreliminarystudy |