Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives
Multiple myeloma (MM) is a hematological malignancy that leads to significant bone destruction, resulting in debilitating pain and skeletal-related events. The pathophysiology of osteolytic bone destruction in MM involves complex interactions between malignant plasma cells (PCs) and the bone marrow...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Journal of Bone Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137425000090 |
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| author | Oxana Lungu Denise Toscani Nicola Giuliani |
| author_facet | Oxana Lungu Denise Toscani Nicola Giuliani |
| author_sort | Oxana Lungu |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a hematological malignancy that leads to significant bone destruction, resulting in debilitating pain and skeletal-related events. The pathophysiology of osteolytic bone destruction in MM involves complex interactions between malignant plasma cells (PCs) and the bone marrow (BM) microenvironment. This review aims to provide a comprehensive synthesis of the cellular and molecular pathways underlying MM-associated bone disease. We discuss the role of osteoclast (OC), osteoblast (OB), osteocytes, along with the complex interactions between immune cells and the BM microenvironment in shaping disease progression. Additionally, we explore the molecular signaling pathways involved in bone disease as well as the influence of inflammatory cytokines, and the role of the metabolic alterations that characterize the MM BM. We also explore novel therapeutic strategies targeting these pathways to improve clinical outcomes. Understanding these mechanisms is crucial for the development of more effective treatments to prevent bone damage in MM patients. |
| format | Article |
| id | doaj-art-176de6c246e0464f94850854a3d8f2fc |
| institution | DOAJ |
| issn | 2212-1374 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj-art-176de6c246e0464f94850854a3d8f2fc2025-08-20T02:50:53ZengElsevierJournal of Bone Oncology2212-13742025-04-015110066810.1016/j.jbo.2025.100668Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectivesOxana Lungu0Denise Toscani1Nicola Giuliani2Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, ItalyLaboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, ItalyLaboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy; Hematology and BMT Unit, “Azienda Ospedaliero-Universitaria di Parma”, Parma, Italy; Corresponding author at: Dept. of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, Italy.Multiple myeloma (MM) is a hematological malignancy that leads to significant bone destruction, resulting in debilitating pain and skeletal-related events. The pathophysiology of osteolytic bone destruction in MM involves complex interactions between malignant plasma cells (PCs) and the bone marrow (BM) microenvironment. This review aims to provide a comprehensive synthesis of the cellular and molecular pathways underlying MM-associated bone disease. We discuss the role of osteoclast (OC), osteoblast (OB), osteocytes, along with the complex interactions between immune cells and the BM microenvironment in shaping disease progression. Additionally, we explore the molecular signaling pathways involved in bone disease as well as the influence of inflammatory cytokines, and the role of the metabolic alterations that characterize the MM BM. We also explore novel therapeutic strategies targeting these pathways to improve clinical outcomes. Understanding these mechanisms is crucial for the development of more effective treatments to prevent bone damage in MM patients.http://www.sciencedirect.com/science/article/pii/S2212137425000090Multiple myelomaBone diseaseOsteoblastsOsteoclastsOsteocytesMolecular pathways |
| spellingShingle | Oxana Lungu Denise Toscani Nicola Giuliani Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives Journal of Bone Oncology Multiple myeloma Bone disease Osteoblasts Osteoclasts Osteocytes Molecular pathways |
| title | Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives |
| title_full | Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives |
| title_fullStr | Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives |
| title_full_unstemmed | Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives |
| title_short | Mechanistic insights into bone destruction in multiple myeloma: Cellular and molecular perspectives |
| title_sort | mechanistic insights into bone destruction in multiple myeloma cellular and molecular perspectives |
| topic | Multiple myeloma Bone disease Osteoblasts Osteoclasts Osteocytes Molecular pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2212137425000090 |
| work_keys_str_mv | AT oxanalungu mechanisticinsightsintobonedestructioninmultiplemyelomacellularandmolecularperspectives AT denisetoscani mechanisticinsightsintobonedestructioninmultiplemyelomacellularandmolecularperspectives AT nicolagiuliani mechanisticinsightsintobonedestructioninmultiplemyelomacellularandmolecularperspectives |