Optimization of approaches to the treatment of mild to moderate ulcerative colitis
Ulcerative colitis is an autoimmune disease of the colon, manifested by the development of non-specific inflammation of its mucous membrane with a mandatory lesion of the rectum. The most common in clinical practice is left-sided ulcerative colitis, a mild or moderate attack. The optimal treatment f...
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| Format: | Article |
| Language: | Russian |
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Open Systems Publication
2021-09-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/792 |
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| author | S. S. Belous O. V. Knyazev |
| author_facet | S. S. Belous O. V. Knyazev |
| author_sort | S. S. Belous |
| collection | DOAJ |
| description | Ulcerative colitis is an autoimmune disease of the colon, manifested by the development of non-specific inflammation of its mucous membrane with a mandatory lesion of the rectum. The most common in clinical practice is left-sided ulcerative colitis, a mild or moderate attack. The optimal treatment for such patients is mesalazine, but the use of the drug with a pH-dependent shell may be limited due to the large variety of pH values in patients with inflammatory bowel diseases. The drugs of choice in such situations are ethylcellulose-coated mesalazine microgranules with prolonged release, which allow to achieve the maximum therapeutic effect. To improve the results of mesalazine therapy, the combined use of a local and systemic drug is necessary. If this approach is ineffective, the use of budesonide MMH may be considered as an alternative to systemic glucocorticosteroids. |
| format | Article |
| id | doaj-art-175ec76a15d5482ba7c623236d02f3e6 |
| institution | Kabale University |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-175ec76a15d5482ba7c623236d02f3e62025-08-20T03:37:06ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-09-0108111610.51793/OS.2021.24.8.002791Optimization of approaches to the treatment of mild to moderate ulcerative colitisS. S. Belous0O. V. Knyazev1Ryzhikh National Medical Research Centre for Coloproctology of the Ministry of Health of the RussiaMoscow Clinical Scientific Center n.a. A. S. LoginovUlcerative colitis is an autoimmune disease of the colon, manifested by the development of non-specific inflammation of its mucous membrane with a mandatory lesion of the rectum. The most common in clinical practice is left-sided ulcerative colitis, a mild or moderate attack. The optimal treatment for such patients is mesalazine, but the use of the drug with a pH-dependent shell may be limited due to the large variety of pH values in patients with inflammatory bowel diseases. The drugs of choice in such situations are ethylcellulose-coated mesalazine microgranules with prolonged release, which allow to achieve the maximum therapeutic effect. To improve the results of mesalazine therapy, the combined use of a local and systemic drug is necessary. If this approach is ineffective, the use of budesonide MMH may be considered as an alternative to systemic glucocorticosteroids.https://journal.lvrach.ru/jour/article/view/792mesalazinetreatment schemetherapyulcerative colitisproctitisleft-side colitisbudesonidesuppositoriadelivery systemmmx |
| spellingShingle | S. S. Belous O. V. Knyazev Optimization of approaches to the treatment of mild to moderate ulcerative colitis Лечащий Врач mesalazine treatment scheme therapy ulcerative colitis proctitis left-side colitis budesonide suppositoria delivery system mmx |
| title | Optimization of approaches to the treatment of mild to moderate ulcerative colitis |
| title_full | Optimization of approaches to the treatment of mild to moderate ulcerative colitis |
| title_fullStr | Optimization of approaches to the treatment of mild to moderate ulcerative colitis |
| title_full_unstemmed | Optimization of approaches to the treatment of mild to moderate ulcerative colitis |
| title_short | Optimization of approaches to the treatment of mild to moderate ulcerative colitis |
| title_sort | optimization of approaches to the treatment of mild to moderate ulcerative colitis |
| topic | mesalazine treatment scheme therapy ulcerative colitis proctitis left-side colitis budesonide suppositoria delivery system mmx |
| url | https://journal.lvrach.ru/jour/article/view/792 |
| work_keys_str_mv | AT ssbelous optimizationofapproachestothetreatmentofmildtomoderateulcerativecolitis AT ovknyazev optimizationofapproachestothetreatmentofmildtomoderateulcerativecolitis |