Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation
Mycophenolate mofetil (MMF), an immunosuppressive, is a pharmacologically inactive compound of mycophenolic acid, which has been widely used in solid organ transplant and autoimmune conditions. It mostly exerts gastrointestinal (GI) adverse effects, which include diarrhea, abdominal pain, nausea, an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043324014031 |
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| author | Hajra Arshad, MD Mohammad Yasrab, MD Alejandra Blanco, MD Jacqueline E Birkness-Gartman, MD Elliot K. Fishman, MD |
| author_facet | Hajra Arshad, MD Mohammad Yasrab, MD Alejandra Blanco, MD Jacqueline E Birkness-Gartman, MD Elliot K. Fishman, MD |
| author_sort | Hajra Arshad, MD |
| collection | DOAJ |
| description | Mycophenolate mofetil (MMF), an immunosuppressive, is a pharmacologically inactive compound of mycophenolic acid, which has been widely used in solid organ transplant and autoimmune conditions. It mostly exerts gastrointestinal (GI) adverse effects, which include diarrhea, abdominal pain, nausea, and vomiting. It can lead to MMF-colitis, a challenging condition to diagnose due to its similarity with other GI-related conditions and infections. This case report discusses a heart transplant recipient who developed severe MMF-induced colitis. It adds significantly to the limited literature available for this difficult-to-diagnose condition. It also highlights the severity of the condition and underscores the importance of vigilant monitoring and the need for future cohort studies to set guidelines for diagnosing and treating MMF-associated colitis due to its widespread use. |
| format | Article |
| id | doaj-art-1751817eefc04e818b2fc0c3133cd45c |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-1751817eefc04e818b2fc0c3133cd45c2025-08-20T02:57:21ZengElsevierRadiology Case Reports1930-04332025-04-012041822182610.1016/j.radcr.2024.12.041Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentationHajra Arshad, MD0Mohammad Yasrab, MD1Alejandra Blanco, MD2Jacqueline E Birkness-Gartman, MD3Elliot K. Fishman, MD4The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA; Corresponding author.The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USAThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USADepartment of Pathology, Division of Gastrointestinal/Liver Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USAThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USAMycophenolate mofetil (MMF), an immunosuppressive, is a pharmacologically inactive compound of mycophenolic acid, which has been widely used in solid organ transplant and autoimmune conditions. It mostly exerts gastrointestinal (GI) adverse effects, which include diarrhea, abdominal pain, nausea, and vomiting. It can lead to MMF-colitis, a challenging condition to diagnose due to its similarity with other GI-related conditions and infections. This case report discusses a heart transplant recipient who developed severe MMF-induced colitis. It adds significantly to the limited literature available for this difficult-to-diagnose condition. It also highlights the severity of the condition and underscores the importance of vigilant monitoring and the need for future cohort studies to set guidelines for diagnosing and treating MMF-associated colitis due to its widespread use.http://www.sciencedirect.com/science/article/pii/S1930043324014031Mycophenolate-associated colitisOrthotopic heart transplantImmunosuppressionGastrointestinal complicationsDrug-associated colitis |
| spellingShingle | Hajra Arshad, MD Mohammad Yasrab, MD Alejandra Blanco, MD Jacqueline E Birkness-Gartman, MD Elliot K. Fishman, MD Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation Radiology Case Reports Mycophenolate-associated colitis Orthotopic heart transplant Immunosuppression Gastrointestinal complications Drug-associated colitis |
| title | Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation |
| title_full | Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation |
| title_fullStr | Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation |
| title_full_unstemmed | Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation |
| title_short | Mycophenolate-associated colitis in an orthotopic heart transplant patient- an unusual case presentation |
| title_sort | mycophenolate associated colitis in an orthotopic heart transplant patient an unusual case presentation |
| topic | Mycophenolate-associated colitis Orthotopic heart transplant Immunosuppression Gastrointestinal complications Drug-associated colitis |
| url | http://www.sciencedirect.com/science/article/pii/S1930043324014031 |
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