Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results
Abstract Background Plasma amyloid-tau-neurodegeneration (ATN) biomarker levels may be influenced by non-brain systems, such as kidney function, which could impact the interpretation of ATN biomarker results, particularly in groups like Hispanic/Latino individuals with higher rates of cardiometaboli...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-025-01786-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850207139442720768 |
|---|---|
| author | Natasha Z. Anita Wassim Tarraf Sayaka Kuwayama Freddie Márquez Charles DeCarli Bharat Thyagarajan Nora Franceschini James P. Lash Tanya Johns Kevin A. González Martha Daviglus Haibo Zhou Ariana M. Stickel Frank J. Penedo Tatjana Rundek Doug Galasko Hector M. González |
| author_facet | Natasha Z. Anita Wassim Tarraf Sayaka Kuwayama Freddie Márquez Charles DeCarli Bharat Thyagarajan Nora Franceschini James P. Lash Tanya Johns Kevin A. González Martha Daviglus Haibo Zhou Ariana M. Stickel Frank J. Penedo Tatjana Rundek Doug Galasko Hector M. González |
| author_sort | Natasha Z. Anita |
| collection | DOAJ |
| description | Abstract Background Plasma amyloid-tau-neurodegeneration (ATN) biomarker levels may be influenced by non-brain systems, such as kidney function, which could impact the interpretation of ATN biomarker results, particularly in groups like Hispanic/Latino individuals with higher rates of cardiometabolic health issues. Here, we examine the association between kidney function and plasma ATN markers among a diverse sample of Hispanic/Latino individuals living in the U.S. Methods Data was collected from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Visit 1, 2008–2011), the largest prospective cohort study of noninstitutionalized Hispanic/Latino adults in the U.S., and its ancillary study, the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) which was conducted during the second visit of the parent HCHS/SOL study (Visit 2, 2015–2018). SOL-INCA aimed to examine the neurocognitive decline of middle-aged and older Hispanic/Latino adults, and the inclusion criteria were the age of 50-years and older by Visit 2 and completion of battery of neurocognitive tests at Visit 1. Survey linear regression models were used to examine associations between CKD status (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73m2 or urine albumin-creatinine ratio [uACR]) > = 30 mg/g) and the plasma ATN biomarkers (β-amyloid 42/40 ratio [Aβ42/40 ratio], phosphorylated-tau181 [p-Tau181], neurofilament light [NfL], and glial fibrillary associated protein [GFAP]), independently. All models adjusted for sociodemographic and cardiometabolic factors (BMI, diabetes, and hypertension). Results 5,968 participants were included in the study (mean age 63.4 ± 8.1, 54% women). CKD was associated with higher p-Tau181 (b = 0.82), NfL (b = 11.60) and GFAP levels (b = 31.41), and lower Aβ42/Aβ40 ratio (b=-0.004). Lower eGFR (i.e., reduced kidney function) was associated with higher p-Tau181, NfL, and GFAP levels (b ranges [-0.87 - -0.03]), and lower Aβ42/Aβ40 ratio (b = 0.000). Higher (natural log) uACR was associated with lower Aβ42/Aβ40 ratio and higher levels of all other biomarkers (b ranges [0.24–5.49]). Additionally, CKD, eGFR, and uACR were associated with ATN biomarkers in models adjusted for cardiometabolic risk factors, diabetes and hypertension. Conclusions CKD status, kidney function and urinary markers of kidney damage are significant confounders in the interpretation of plasma ATN biomarker levels. |
| format | Article |
| id | doaj-art-174ebcd50a47464c95940fc112671a82 |
| institution | OA Journals |
| issn | 1758-9193 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj-art-174ebcd50a47464c95940fc112671a822025-08-20T02:10:36ZengBMCAlzheimer’s Research & Therapy1758-91932025-06-0117111110.1186/s13195-025-01786-8Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL resultsNatasha Z. Anita0Wassim Tarraf1Sayaka Kuwayama2Freddie Márquez3Charles DeCarli4Bharat Thyagarajan5Nora Franceschini6James P. Lash7Tanya Johns8Kevin A. González9Martha Daviglus10Haibo Zhou11Ariana M. Stickel12Frank J. Penedo13Tatjana Rundek14Doug Galasko15Hector M. González16Department of Neurosciences, University of California, San DiegoInstitute of Gerontology & Department of Healthcare Sciences, Wayne State UniversityDepartment of Neurosciences, University of California, San DiegoDepartment of Neurosciences, University of California, San DiegoDepartment of Neurology, University of California, DavisDepartment of Laboratory Medicine and Pathology, University of MinnesotaDepartment of Epidemiology, Gillings School of Public Health, University of North Carolina at Chapel HillDepartment of Medicine, University of Illinois ChicagoDepartment of Medicine, Division of Nephrology, Albert Einstein College of Medicine/Montefiore Medical CenterDepartment of Neurosciences, University of California, San DiegoInstitute for Minority Health Research, College of Medicine, University of Illinois ChicagoDepartment of Biostatistics, University of North Carolina at Chapel HillDepartment of Psychology, San Diego State UniversityDepartments of Psychology and Medicine, University of MiamiDepartment of Neurology and Evelyn F. McKnight Brain Institute, University of MiamiDepartment of Neurosciences, University of California, San DiegoDepartment of Neurosciences, University of California, San DiegoAbstract Background Plasma amyloid-tau-neurodegeneration (ATN) biomarker levels may be influenced by non-brain systems, such as kidney function, which could impact the interpretation of ATN biomarker results, particularly in groups like Hispanic/Latino individuals with higher rates of cardiometabolic health issues. Here, we examine the association between kidney function and plasma ATN markers among a diverse sample of Hispanic/Latino individuals living in the U.S. Methods Data was collected from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Visit 1, 2008–2011), the largest prospective cohort study of noninstitutionalized Hispanic/Latino adults in the U.S., and its ancillary study, the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) which was conducted during the second visit of the parent HCHS/SOL study (Visit 2, 2015–2018). SOL-INCA aimed to examine the neurocognitive decline of middle-aged and older Hispanic/Latino adults, and the inclusion criteria were the age of 50-years and older by Visit 2 and completion of battery of neurocognitive tests at Visit 1. Survey linear regression models were used to examine associations between CKD status (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73m2 or urine albumin-creatinine ratio [uACR]) > = 30 mg/g) and the plasma ATN biomarkers (β-amyloid 42/40 ratio [Aβ42/40 ratio], phosphorylated-tau181 [p-Tau181], neurofilament light [NfL], and glial fibrillary associated protein [GFAP]), independently. All models adjusted for sociodemographic and cardiometabolic factors (BMI, diabetes, and hypertension). Results 5,968 participants were included in the study (mean age 63.4 ± 8.1, 54% women). CKD was associated with higher p-Tau181 (b = 0.82), NfL (b = 11.60) and GFAP levels (b = 31.41), and lower Aβ42/Aβ40 ratio (b=-0.004). Lower eGFR (i.e., reduced kidney function) was associated with higher p-Tau181, NfL, and GFAP levels (b ranges [-0.87 - -0.03]), and lower Aβ42/Aβ40 ratio (b = 0.000). Higher (natural log) uACR was associated with lower Aβ42/Aβ40 ratio and higher levels of all other biomarkers (b ranges [0.24–5.49]). Additionally, CKD, eGFR, and uACR were associated with ATN biomarkers in models adjusted for cardiometabolic risk factors, diabetes and hypertension. Conclusions CKD status, kidney function and urinary markers of kidney damage are significant confounders in the interpretation of plasma ATN biomarker levels.https://doi.org/10.1186/s13195-025-01786-8KidneyRenalAlzheimer's diseaseDementiaBiomarkers |
| spellingShingle | Natasha Z. Anita Wassim Tarraf Sayaka Kuwayama Freddie Márquez Charles DeCarli Bharat Thyagarajan Nora Franceschini James P. Lash Tanya Johns Kevin A. González Martha Daviglus Haibo Zhou Ariana M. Stickel Frank J. Penedo Tatjana Rundek Doug Galasko Hector M. González Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results Alzheimer’s Research & Therapy Kidney Renal Alzheimer's disease Dementia Biomarkers |
| title | Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results |
| title_full | Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results |
| title_fullStr | Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results |
| title_full_unstemmed | Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results |
| title_short | Kidney function is associated with plasma ATN biomarkers among Hispanics/Latinos: SOL-INCA and HCHS/SOL results |
| title_sort | kidney function is associated with plasma atn biomarkers among hispanics latinos sol inca and hchs sol results |
| topic | Kidney Renal Alzheimer's disease Dementia Biomarkers |
| url | https://doi.org/10.1186/s13195-025-01786-8 |
| work_keys_str_mv | AT natashazanita kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT wassimtarraf kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT sayakakuwayama kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT freddiemarquez kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT charlesdecarli kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT bharatthyagarajan kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT norafranceschini kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT jamesplash kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT tanyajohns kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT kevinagonzalez kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT marthadaviglus kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT haibozhou kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT arianamstickel kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT frankjpenedo kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT tatjanarundek kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT douggalasko kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults AT hectormgonzalez kidneyfunctionisassociatedwithplasmaatnbiomarkersamonghispanicslatinossolincaandhchssolresults |