QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression

QRICH1 regulates ATF6 transcription to affect pathological cardiac hypertrophy progression

Abstract Background Many studies have shown that pathological cardiac hypertrophy is associated with active endoplasmic reticulum (ER) stress. Glutamine-rich protein 1 (QRICH1), as a transcriptional regulator, belongs to the caspase recruitment domain (CARD)-containing gene family. QRICH1 has been s...

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Bibliographic Details
Main Authors: Lihui Zhang, Hongping Chen, Guangmei Zou, Wenjuan Jia, Haibin Dong, Chunxiao Wang, Hua Wang, Yugang Liu, Da Teng, Bowen Xu, Lin Zhong, Lei Gong, Jun Yang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Cardiac remodeling
Heart failure
Endoplasmic reticulum stress
Pressure overload
Online Access:https://doi.org/10.1186/s10020-025-01241-2
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