Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China
Nitric oxide (NO) is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS) gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/891581 |
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| author | Yingjie Dai Zhiyi He Rubo Sui Zhilin Jiang Shanshan Ma |
| author_facet | Yingjie Dai Zhiyi He Rubo Sui Zhilin Jiang Shanshan Ma |
| author_sort | Yingjie Dai |
| collection | DOAJ |
| description | Nitric oxide (NO) is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS) gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757). Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P=0.037, P=0.041). After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes), AG genotype and A allele were still related to ischemic stroke (OR=0.572, 95% CI: 0.335–0.978, P=0.041; OR=0.611, 95% C: 0.378–0.985, and P=0.041) and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China. |
| format | Article |
| id | doaj-art-174dccf4cfa54d4a93514cf8f635eee3 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-174dccf4cfa54d4a93514cf8f635eee32025-08-20T03:54:33ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/891581891581Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North ChinaYingjie Dai0Zhiyi He1Rubo Sui2Zhilin Jiang3Shanshan Ma4Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Neurology, NO 202 Hospital of People’s Liberation Army of China, Shenyang 110001, ChinaDepartment of Neurology, Jinqiu Hospital of China Liaoning Province, Shenyang 110001, ChinaNitric oxide (NO) is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS) gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757). Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P=0.037, P=0.041). After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes), AG genotype and A allele were still related to ischemic stroke (OR=0.572, 95% CI: 0.335–0.978, P=0.041; OR=0.611, 95% C: 0.378–0.985, and P=0.041) and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.http://dx.doi.org/10.1155/2013/891581 |
| spellingShingle | Yingjie Dai Zhiyi He Rubo Sui Zhilin Jiang Shanshan Ma Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China The Scientific World Journal |
| title | Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China |
| title_full | Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China |
| title_fullStr | Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China |
| title_full_unstemmed | Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China |
| title_short | Association of nNOS Gene Polymorphism with Ischemic Stroke in Han Chinese of North China |
| title_sort | association of nnos gene polymorphism with ischemic stroke in han chinese of north china |
| url | http://dx.doi.org/10.1155/2013/891581 |
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