Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

Several studies have revealed that midbrain dopamine (DA) neurons, even within a single neuroanatomical area, display heterogeneous properties. In parallel, studies using singlecell profiling techniques have begun to cluster DA neurons into subtypes based on their molecular signatures. Recent work h...

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Bibliographic Details
Main Authors: Zachary Gaertner, Cameron Oram, Amanda Schneeweis, Elan Schonfeld, Cyril Bolduc, Chuyu Chen, Daniel Dombeck, Loukia Parisiadou, Jean-Francois Poulin, Rajeshwar Awatramani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
Lrrk2
dopamine
transcriptomics
subtypes
spatial
Parkinson's disease
Online Access:https://elifesciences.org/articles/101035
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