EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY
One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Fecal elastase 1 is a good marker of pancreatic exocrine secretion. The aim of the study was to evaluate the pancreatic exocrine secretion in children with type 1 diabetes mellitus with fecal elast...
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"Paediatrician" Publishers LLC
2013-02-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/389 |
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| author | A. A. Nizhevich G. M. Yakupova O. A. Malievskii E. N. Akhmadeeva A. M. Farkhutdinova |
| author_facet | A. A. Nizhevich G. M. Yakupova O. A. Malievskii E. N. Akhmadeeva A. M. Farkhutdinova |
| author_sort | A. A. Nizhevich |
| collection | DOAJ |
| description | One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Fecal elastase 1 is a good marker of pancreatic exocrine secretion. The aim of the study was to evaluate the pancreatic exocrine secretion in children with type 1 diabetes mellitus with fecal elastase 1 test to estimate the possible need for exogenous pancreatic enzyme replacement therapy. The exocrine pancreatic function was evaluated in 54 diabetic children on the basis of steatocrite test and a determination of fecal elastase 1 concentrations. Compared to the controls, the diabetic children had significantly lower levels of fecal elastase 1 concentration (p<0,001). Steatorrhoea was registered in all patients with fecal elastase 1 level < 200 µg/g stool. All those patients were treated with pancreatin (creon) for 1 month. A reduction of fat excretion was observed in the pancreatin treated group at the end of the study. Pancreatin replacement therapy can be used safely in children with type 1 diabetes mellitus associated with exocrine pancreatic insufficiency. |
| format | Article |
| id | doaj-art-174656d808c046beacafd5c4e354a03a |
| institution | DOAJ |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-174656d808c046beacafd5c4e354a03a2025-08-20T03:21:13Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352013-02-0112118118510.15690/vsp.v12i1.578389EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGYA. A. Nizhevich0G. M. Yakupova1O. A. Malievskii2E. N. Akhmadeeva3A. M. Farkhutdinova4Bashkir State Medical University, the Republic of BashkortostanChildren’s Republican Hospital, Ufa, the Republic of BashkortostanBashkir State Medical University, the Republic of BashkortostanBashkir State Medical University, the Republic of BashkortostanChildren’s Republican Hospital, Ufa, the Republic of BashkortostanOne of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Fecal elastase 1 is a good marker of pancreatic exocrine secretion. The aim of the study was to evaluate the pancreatic exocrine secretion in children with type 1 diabetes mellitus with fecal elastase 1 test to estimate the possible need for exogenous pancreatic enzyme replacement therapy. The exocrine pancreatic function was evaluated in 54 diabetic children on the basis of steatocrite test and a determination of fecal elastase 1 concentrations. Compared to the controls, the diabetic children had significantly lower levels of fecal elastase 1 concentration (p<0,001). Steatorrhoea was registered in all patients with fecal elastase 1 level < 200 µg/g stool. All those patients were treated with pancreatin (creon) for 1 month. A reduction of fat excretion was observed in the pancreatin treated group at the end of the study. Pancreatin replacement therapy can be used safely in children with type 1 diabetes mellitus associated with exocrine pancreatic insufficiency.https://vsp.spr-journal.ru/jour/article/view/389childrendiabetesmellitusexocrine pancreatic insufficiencyfecal elastasesteatocritpancreatin |
| spellingShingle | A. A. Nizhevich G. M. Yakupova O. A. Malievskii E. N. Akhmadeeva A. M. Farkhutdinova EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY Вопросы современной педиатрии children diabetes mellitus exocrine pancreatic insufficiency fecal elastase steatocrit pancreatin |
| title | EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY |
| title_full | EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY |
| title_fullStr | EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY |
| title_full_unstemmed | EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY |
| title_short | EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY |
| title_sort | exocrine pancreatic insufficiency in children with type 1 diabetes mellitus a new problem of pediatric gastroenterology |
| topic | children diabetes mellitus exocrine pancreatic insufficiency fecal elastase steatocrit pancreatin |
| url | https://vsp.spr-journal.ru/jour/article/view/389 |
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